Subclinical Hypothyroidism during Quetiapine Treatment : A Case Report

Quetiapine 치료 중 발생한 무증상 갑상선 기능저하증 1례

  • Na, Kyeong-Sae (Department of Psychiatry, Korea University College of Medicine, Ansan Hospital) ;
  • Kim, Yong-Ku (Department of Psychiatry, Korea University College of Medicine, Ansan Hospital)
  • 나경세 (고려대학교 의과대학 안산병원 정신과학교실) ;
  • 김용구 (고려대학교 의과대학 안산병원 정신과학교실)
  • Published : 2007.02.28

Abstract

Quetiapine is an atypical antipsychotic drug with a benign side effect profile. However, recent studies have reported that thyroid dysfunction is associated with quetiapine treatment. The authors report a patient with DSM-IV bipolar I disorder who developed subclinical hypothyroidism during quetiapine treatment. The patient showed no significant clinical symptoms, but only abnormal thyroid function test findings including antithyroglobulin antibody. The abnormal thyroid function test findings were normalized after discontinuation of quetiapine. The subclinical hypothyroidism developed during quetiapine treatment may be associated with autoimmune process.

Keywords