Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Screening of Korean Marine Plants Extracts for Inhibitory Activity on Protein Tyrosine Phosphatase 1B

  • Lee, Hee-Jung (Busan Regional Food & Drug Administration, Test & Analysis Center) ;
  • Kim, You-Ah (Division of Marine Environment and Bioscience, Korea Maritime University) ;
  • Lee, Jung-Im (Division of Marine Environment and Bioscience, Korea Maritime University) ;
  • Lee, Burm-Jong (Department of Chemistry, Inje University) ;
  • Seo, Young-Wan (Division of Marine Environment and Bioscience, Korea Maritime University)
  • Published : 2007.06.30
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Abstract

Crude extracts of 69 marine organisms (27 salt marsh plants and 42 seaweeds) were screened for the inhibitory activity against the protein tyrosine phosphatase 1B (PTP1) in vitro. The most active extracts were methanol extracts from Derbesia marina (80.6% in inhibitory activity) and Symphycladia latiscula (85.6%) at the concentration of $15{\mu}g/mL$. Methanol extracts of Codium adhaerens and Hisikia fuziformis were moderately inhibitory with 71.2 and 69.1% inhibition, respectively. It was peculiar that only the extracts from seaweeds show inhibitory activity where those from salt marsh plants do not show any significant effect.

Keywords

References

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