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Screening of Korean Marine Plants Extracts for Inhibitory Activity on Protein Tyrosine Phosphatase 1B  

Lee, Hee-Jung (Busan Regional Food & Drug Administration, Test & Analysis Center)
Kim, You-Ah (Division of Marine Environment and Bioscience, Korea Maritime University)
Lee, Jung-Im (Division of Marine Environment and Bioscience, Korea Maritime University)
Lee, Burm-Jong (Department of Chemistry, Inje University)
Seo, Young-Wan (Division of Marine Environment and Bioscience, Korea Maritime University)
Publication Information
Journal of Applied Biological Chemistry / v.50, no.2, 2007 , pp. 74-77 More about this Journal
Abstract
Crude extracts of 69 marine organisms (27 salt marsh plants and 42 seaweeds) were screened for the inhibitory activity against the protein tyrosine phosphatase 1B (PTP1) in vitro. The most active extracts were methanol extracts from Derbesia marina (80.6% in inhibitory activity) and Symphycladia latiscula (85.6%) at the concentration of $15{\mu}g/mL$. Methanol extracts of Codium adhaerens and Hisikia fuziformis were moderately inhibitory with 71.2 and 69.1% inhibition, respectively. It was peculiar that only the extracts from seaweeds show inhibitory activity where those from salt marsh plants do not show any significant effect.
Keywords
diabetes mellitus; protein tyrosine phosphatase 1B; salt marsh plant; seaweed;
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Times Cited By KSCI : 5  (Citation Analysis)
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