Farnesyl Protein Transferase Inhibitory Components of Lithospermum erythrorhizon

  • Kim, Seong-Jin (College of Pharmacy, Woosuk University) ;
  • Kwon, Byoung-Mog (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Kim, Sung-Hoon (Lab. of Angiogenesis and Chemoprevention, Department of Oriental Pathology, College of Oriental Medicine, Kyunghee University) ;
  • Baek, Nam-In (Graduate School of Biotechnology & Plant Metabolism Research Center, KyungHee University) ;
  • Yang, Jae-Heon (College of Pharmacy, Woosuk University) ;
  • Lee, Jeong-Joo (College of Pharmacy, Woosuk University) ;
  • Lee, Sa-Im (College of Pharmacy, Woosuk University) ;
  • Kwon, Young-Ee (College of Pharmacy, Woosuk University) ;
  • Park, Hee-Wook (College of Pharmacy, Woosuk University) ;
  • Lee, Jae-Hyeok (Depart. of Oriental Pharmaceutical Development, Nambu University) ;
  • Park, Jeong-Suk (Depart. of Oriental Alternative Medicine, Nambu University) ;
  • Kim, Dae-Keun (College of Pharmacy, Woosuk University)
  • Published : 2007.12.31

Abstract

The methanolic extract of the roots of Lithospermum erythrorhizon (Boraginaceae) was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of three naphthoquinone compounds, as inhibitors of FPTase. These compounds inhibited the FPTase activity in a dose-dependent manner.

Keywords

References

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