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Farnesyl Protein Transferase Inhibitory Components of Lithospermum erythrorhizon  

Kim, Seong-Jin (College of Pharmacy, Woosuk University)
Kwon, Byoung-Mog (Korea Research Institute of Bioscience and Biotechnology, KIST)
Kim, Sung-Hoon (Lab. of Angiogenesis and Chemoprevention, Department of Oriental Pathology, College of Oriental Medicine, Kyunghee University)
Baek, Nam-In (Graduate School of Biotechnology & Plant Metabolism Research Center, KyungHee University)
Yang, Jae-Heon (College of Pharmacy, Woosuk University)
Lee, Jeong-Joo (College of Pharmacy, Woosuk University)
Lee, Sa-Im (College of Pharmacy, Woosuk University)
Kwon, Young-Ee (College of Pharmacy, Woosuk University)
Park, Hee-Wook (College of Pharmacy, Woosuk University)
Lee, Jae-Hyeok (Depart. of Oriental Pharmaceutical Development, Nambu University)
Park, Jeong-Suk (Depart. of Oriental Alternative Medicine, Nambu University)
Kim, Dae-Keun (College of Pharmacy, Woosuk University)
Publication Information
Natural Product Sciences / v.13, no.4, 2007 , pp. 328-331 More about this Journal
Abstract
The methanolic extract of the roots of Lithospermum erythrorhizon (Boraginaceae) was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of three naphthoquinone compounds, as inhibitors of FPTase. These compounds inhibited the FPTase activity in a dose-dependent manner.
Keywords
Lithospermum erythrorhizon; Boraginaceae; naphthoquinone; FPTase;
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Times Cited By KSCI : 3  (Citation Analysis)
Times Cited By SCOPUS : 1
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