생명과학회지 (Journal of Life Science)

  • 제17권11호
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  • Pages.1587-1592
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  • 2007
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  • 1225-9918(pISSN)
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  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
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Locus Control Region의 구조와 기능

The Structure and Function of Locus Control Region

  • 김애리 (부산대학교 자연과학대학 생명과학부)
  • Kim, Ae-Ri (School of Life Sciences, College of Natural Sciences, Pusan National University)
  • 발행 : 2007.11.30
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초록

Locus control region (LCR) is a cia-acting element which regulates the transcription of genes in developmental stage and/or tissue-specific pattern. Typically, LCR consists of several DNase I hypersensitive sites (HSs), where the binding motifs for transcriptional activators are present. The binding of activators to the HSs recruits chromatin modifying complexes to the LCR, opening chromatin structure and modifying histones covalently through the locus. LCR forms close physical contact with target gene located at a distance by looping away intervening region. In addition, non-coding RNA is transcribed from LCR toward target genes in continuously acetylated active domain. These structural and functional features of LCR suggest that the LCR plays many roles in chromatin activation and transcriptional regulation.

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참고문헌

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