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Ester Derivatives from Tannase-treated Prunioside A and Their Anti-inflammatory Activities

  • Jun, Chang-Soo (Department of Bionanochemistry and Basic Sciences Research Institute, Wonkwang University) ;
  • Yoo, Myung-Ja (Department of Bionanochemistry and Basic Sciences Research Institute, Wonkwang University) ;
  • Lee, Woo-Yiel (Department of Pharmaceutical Engineering, Konyang University) ;
  • Kwak, Kyung-Chell (Department of Bionanochemistry and Basic Sciences Research Institute, Wonkwang University) ;
  • Bae, Moon-Sung (Department of Bionanochemistry and Basic Sciences Research Institute, Wonkwang University) ;
  • Hwang, Woo-Taek (Department of Bionanochemistry and Basic Sciences Research Institute, Wonkwang University) ;
  • Son, Dong-Hwan (College of Pharmacy, Wonkwang University) ;
  • Chai, Kyu-Yun (Department of Bionanochemistry and Basic Sciences Research Institute, Wonkwang University)
  • 발행 : 2007.01.20

초록

Prunioside A, isolated from the methanol extract of Spiraea prunifolia var. Simpliciflora's root, is composed of coumaroyl, monoterpene-type, and glucosyl units. The esterase activity of tannase was used to remove the p-coumaroyl and glucopyranosyl groups. The enzymatically hydrolyzed compound was reacted with various acyl chlorides to synthesize its ester derivatives, which showed the inhibitory effects on NO production in murine machrophage?like RAW 264.7 cells stimulated with lipopolysaccharide and interferon-γ.

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참고문헌

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  5. 조팝나무(Spiraea prunifolia var. simpliciflora)로부터 분리한 페놀 화합물의 신경세포 보호효과 vol.61, pp.4, 2007, https://doi.org/10.3839/jabc.2018.056
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