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http://dx.doi.org/10.5012/bkcs.2007.28.1.073

Ester Derivatives from Tannase-treated Prunioside A and Their Anti-inflammatory Activities  

Jun, Chang-Soo (Department of Bionanochemistry and Basic Sciences Research Institute, Wonkwang University)
Yoo, Myung-Ja (Department of Bionanochemistry and Basic Sciences Research Institute, Wonkwang University)
Lee, Woo-Yiel (Department of Pharmaceutical Engineering, Konyang University)
Kwak, Kyung-Chell (Department of Bionanochemistry and Basic Sciences Research Institute, Wonkwang University)
Bae, Moon-Sung (Department of Bionanochemistry and Basic Sciences Research Institute, Wonkwang University)
Hwang, Woo-Taek (Department of Bionanochemistry and Basic Sciences Research Institute, Wonkwang University)
Son, Dong-Hwan (College of Pharmacy, Wonkwang University)
Chai, Kyu-Yun (Department of Bionanochemistry and Basic Sciences Research Institute, Wonkwang University)
Publication Information
Bulletin of the Korean Chemical Society / v.28, no.1, 2007 , pp. 73-76 More about this Journal
Abstract
Prunioside A, isolated from the methanol extract of Spiraea prunifolia var. Simpliciflora's root, is composed of coumaroyl, monoterpene-type, and glucosyl units. The esterase activity of tannase was used to remove the p-coumaroyl and glucopyranosyl groups. The enzymatically hydrolyzed compound was reacted with various acyl chlorides to synthesize its ester derivatives, which showed the inhibitory effects on NO production in murine machrophage?like RAW 264.7 cells stimulated with lipopolysaccharide and interferon-γ.
Keywords
Spiraea prunifolia; Prunioside A; Nitric oxide; NO production; Inhibitory effects;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 2  (Related Records In Web of Science)
Times Cited By SCOPUS : 2
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