Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Boronated Porphyrins and Chlorins as Potential Anticancer Drugs

  • Ol'shevskaya, Valentina A. (A.N. Nesmeyanov Institute of Organoelement Compounds) ;
  • Zaytsev, Andrey V. (A.N. Nesmeyanov Institute of Organoelement Compounds) ;
  • Savchenko, Arina N. (A.N. Nesmeyanov Institute of Organoelement Compounds) ;
  • Shtil, Alexander A. (N.N. Blokhin Cancer Center) ;
  • Cheong, Chan-Seong (Korea Institute of Science and Technology) ;
  • Kalinin, Valery N. (A.N. Nesmeyanov Institute of Organoelement Compounds)
  • Published : 2007.11.20
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Abstract

Analyzed are recent advances in design of novel boronared conjugates of synthetic and natural porphyrins and chlorins. These compounds showed high efficacy as cytotoxic agents for tumor cells in culture and as phototoxins in photodynamic therapy of tumor xenografts. Thus, boronated porphyrins and chlorins emerge as promising class of anticancer agents with potentially multiple advantages: the chemotherapeutic drugs alone and photo- and radiosensitizers in binary treatments.

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References

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