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http://dx.doi.org/10.5012/bkcs.2007.28.11.1910

Boronated Porphyrins and Chlorins as Potential Anticancer Drugs  

Ol'shevskaya, Valentina A. (A.N. Nesmeyanov Institute of Organoelement Compounds)
Zaytsev, Andrey V. (A.N. Nesmeyanov Institute of Organoelement Compounds)
Savchenko, Arina N. (A.N. Nesmeyanov Institute of Organoelement Compounds)
Shtil, Alexander A. (N.N. Blokhin Cancer Center)
Cheong, Chan-Seong (Korea Institute of Science and Technology)
Kalinin, Valery N. (A.N. Nesmeyanov Institute of Organoelement Compounds)
Publication Information
Bulletin of the Korean Chemical Society / v.28, no.11, 2007 , pp. 1910-1916 More about this Journal
Abstract
Analyzed are recent advances in design of novel boronared conjugates of synthetic and natural porphyrins and chlorins. These compounds showed high efficacy as cytotoxic agents for tumor cells in culture and as phototoxins in photodynamic therapy of tumor xenografts. Thus, boronated porphyrins and chlorins emerge as promising class of anticancer agents with potentially multiple advantages: the chemotherapeutic drugs alone and photo- and radiosensitizers in binary treatments.
Keywords
Carboranes; Porphyrins; Drug resistance; Photodynamic therapy; Boron neutron capture therapy;
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