Macromolecular Research

The Polymer Society of Korea (한국고분자학회)
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Adsorption of Nucleotides on ${\beta}$-Cyclodextrin Derivative Grafted Chitosan

  • Xiao Jian-Bo (College of Chemistry and Chemical Engineering, Central South University) ;
  • Yu Hong-Zhu (College of Chemistry and Chemical Engineering, Central South University) ;
  • Xu Ming (Research Institute for Molecular Pharmacology and Therapeutics, Central South University, Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center) ;
  • Chen Xiao-Qing (College of Chemistry and Chemical Engineering, Central South University)
  • Published : 2006.08.01
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Abstract

A novel ${\beta}$-cyclodextrin derivative (CCD-C) was synthesized with chitosan and carboxymethyl-${\beta}$-cyclodextrin. Its structure was characterized by elemental analysis, infrared spectra analysis, and X-ray diffraction analysis. The adsorption properties for guanosine 5'-monophosphate, cytidine 5'-monophosphate and uridine 5'-monophosphate were studied. Experimental results demonstrated that CCD-C had higher adsorption capability for guanosine 5'-monophosphate, and that the adsorption capacity for guanosine 5'-monophosphate was 74.20mg/g. The adsorption capacity was greatly influenced by pH, time and temperature. The introduction of chitosan enhanced the adsorption ability and adsorption selectivity of ${\beta}$-cyclodextrin for guanosine 5'-monophosphate. This novel derivative of chitosan is expected to have wide applications in the separation, concentration and analysis of nucleotides in biological samples.

Keywords

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