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Adsorption of Nucleotides on ${\beta}$-Cyclodextrin Derivative Grafted Chitosan  

Xiao Jian-Bo (College of Chemistry and Chemical Engineering, Central South University)
Yu Hong-Zhu (College of Chemistry and Chemical Engineering, Central South University)
Xu Ming (Research Institute for Molecular Pharmacology and Therapeutics, Central South University, Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center)
Chen Xiao-Qing (College of Chemistry and Chemical Engineering, Central South University)
Publication Information
Macromolecular Research / v.14, no.4, 2006 , pp. 443-448 More about this Journal
Abstract
A novel ${\beta}$-cyclodextrin derivative (CCD-C) was synthesized with chitosan and carboxymethyl-${\beta}$-cyclodextrin. Its structure was characterized by elemental analysis, infrared spectra analysis, and X-ray diffraction analysis. The adsorption properties for guanosine 5'-monophosphate, cytidine 5'-monophosphate and uridine 5'-monophosphate were studied. Experimental results demonstrated that CCD-C had higher adsorption capability for guanosine 5'-monophosphate, and that the adsorption capacity for guanosine 5'-monophosphate was 74.20mg/g. The adsorption capacity was greatly influenced by pH, time and temperature. The introduction of chitosan enhanced the adsorption ability and adsorption selectivity of ${\beta}$-cyclodextrin for guanosine 5'-monophosphate. This novel derivative of chitosan is expected to have wide applications in the separation, concentration and analysis of nucleotides in biological samples.
Keywords
chitosan; carboxymethyl-${\beta}$-cyclodextrin; nucleotides; adsorption;
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