Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Gemcitabine-Induced Radiation Recall Dermato-Myositis

Gemcitabine 투여 후 발생한 방사선 회귀 피부, 근육염

  • No, Hee Sun (Department of Internal Medicine, Korea Cancer Center Hospital) ;
  • Lim, Hee Hwan (Department of Internal Medicine, Korea Cancer Center Hospital) ;
  • Kim, Jung Hoon (Department of Internal Medicine, Korea Cancer Center Hospital) ;
  • Cho, Jang Hyun (Department of Internal Medicine, Korea Cancer Center Hospital) ;
  • Huh, Jeong Kwon (Department of Internal Medicine, Korea Cancer Center Hospital) ;
  • Cho, Sung In (Department of Internal Medicine, Korea Cancer Center Hospital) ;
  • Yoo, Ji Young (Department of Radiology, Korea Cancer Center Hospital) ;
  • Kim, Cheol Hyeon (Department of Internal Medicine, Korea Cancer Center Hospital) ;
  • Lee, Jae Cheol (Department of Internal Medicine, Korea Cancer Center Hospital)
  • Received : 2006.05.25
  • Accepted : 2006.07.12
  • Published : 2006.08.30
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Abstract

A radiation recall reaction refers to an inflammatory reaction at previous irradiated areas subsequent to the administration of a variety of pharmacological agents. The skin is the major site of radiation recall reactons with the muscle and internal organs being less commonly affected. These reactions usually occur days to weeks after exposure to the causative agents. We report a case of gemcitabine-induced radiation recall dermato-myositis the developed in a female patient with a metastatic non-small cell lung cancer. She had received a palliative radiation therapy of 3900 cGy to the metastatic lesion on the femur shaft prior to chemotherapy. The pain, swelling and erythema of the left thigh resolved after the cessation of gemcitabine and the use of a systemic steroid.

대퇴골 전이를 동반한 비소세포폐암 환자에서 전이 부위에 대한 방사선 치료 후 시행한 항암화학요법 도중, gemcitabine으로 인한 방사선 회귀 피부, 근육염이 발생하였다. 대퇴부의 부종, 발적과 통증 등은 스테로이드 사용 후 모두 사라졌으며, gemcitabine 투여를 중지한 이후 현재까지 재발이 없었다.

Keywords

References

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