Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Effects of Aucuba japonica Extract on Oral Wound Healing

구강점막의 창상치유에 대한 식나무(Aucuba japonica) 추출물의 효과

  • Shim Kyung-Mi (College of Veterinary Medicine, Chonnam National University) ;
  • Kim Se-Eun (College of Veterinary Medicine, Chonnam National University) ;
  • Choi Jeong-Yun (Department of Oral Histology College of Dentistry, Chosun University) ;
  • Park Joo-Cheol (Department of Oral Histology College of Dentistry, Chosun University) ;
  • Jeong Soon-Jeong (Department of Oral Histology College of Dentistry, Chosun University) ;
  • Lee Jae-Yeong (College of Veterinary Medicine, Chonnam National University) ;
  • Bae Chun-Sik (College of Veterinary Medicine, Chonnam National University) ;
  • Park Don-Hee (School of Biological Science and Technology, Chonnam National University) ;
  • Kim Do-Man (School of Biological Science and Technology, Chonnam National University) ;
  • Jeong Moon-Jin (Department of Oral Histology College of Dentistry, Chosun University) ;
  • Kang Seong-Soo (College of Veterinary Medicine, Chonnam National University)
  • 심경미 (전남대학교 수의과대학) ;
  • 김세은 (전남대학교 수의과대학) ;
  • 최정윤 (조선대학교 치과대학 구강조직학교실) ;
  • 박주철 (조선대학교 치과대학 구강조직학교실) ;
  • 정순정 (조선대학교 치과대학 구강조직학교실) ;
  • 이재영 (전남대학교 수의과대학) ;
  • 배춘식 (전남대학교 수의과대학) ;
  • 박돈희 (전남대학교 생명과학기술학부) ;
  • 김도만 (전남대학교 생명과학기술학부) ;
  • 정문진 (조선대학교 치과대학 구강조직학교실) ;
  • 강성수 (전남대학교 수의과대학)
  • Published : 2006.03.01
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Abstract

Aucuba japonica has variable pharmacological effects such as hepatoprotective, choleretic, hemodynamic, antimicrobial, and anti-inflammatory activities. This study was performed to investigate the effects of Aucuba japonica extract on oral wound healing. Aucubin was extracted from Aucuba japonica, and injected on either side of buccal mucosa of male mice. Artificial full thickness wounds were made on the site with 1.5 mm biopsy punch under sterile technique. The specimens had taken on day 1, 3, and 5 with 4 mm biopsy punch. Light microscopic examination and quantitative histologic analysis were performed for reepithelization, inflammatory cell infiltration. Reepithelization of the aucubin (0.1%) group was earlier than the control group. And the number of inflammatory cells of the aucubin group was lesser than the control group. In view of the results so far achieved, the aucubin extracted from Aucuba japonica may be useful for oral wound healing and it can be applied as a topical agent on the oral wound. Further research should be performed on the mechanism of aucubin on oral wound healing and proper formulation for effective topical agents.

Keywords

References

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