Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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The Application of Quantitative Electroencephalography (Spectral Edge Frequency 95) to Evaluate Sedation in Dogs

개에서 진정 평가를 위한 정량적 뇌파검사의 적용

  • Kim Min-Su (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University) ;
  • Nam Tchi-Chou (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University)
  • Published : 2006.03.01
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Abstract

This study was performed to evaluate sedation with quantitative electroencephalography (EEG) analysis in dogs. EEG is used to evaluate objectively the effects of CNS acting with brain and behavioral changes. Especially, spectral edge frequency 95 (SEF 95) parameter is an effective method to determine the sedative status. The SEF 95 is the frequency below 95% of the total power. Twelve healthy intact male Miniature Schnauzer dogs, which did not show any neurological abnormalities and disease, were used for the study. EEG electrodes were inserted in subcutaneous tissue over the calvaria without entering adjacent muscles. The EEG data were acquired and analyzed by EEG raw wave and spectral edge frequency 95 analysis. After the administration of sedatives, the SEF 95 values were shown the significant changes compared with the normal state In all groups (p<0.05). It is suggested that SEF 95 analysis is useful method for assessing the state of sedation in dogs.

본 연구는 건강한 12마리의 슈나우져견에서 정량적 뇌파검사를 이용하여 진정을 평가한 것이다. 뇌파검사는 뇌나 행동의 변화와 관련된 중추신경계의 변화를 객관적으로 측정하는 데 사용이 된다. 특히 정량적 뇌파검사 방법인 spectral edge frequency 95 (SEF 95)는 진정의 상태를 평가하는 효과적인 방법이다. 본 실험에서 뇌파 전극은 8곳의 각각 다른 부위의 피하에 장착 하였으며 뇌파의 원래 파형과 SEF 95로 변환된 수치를 획득하여 분석하였다. 기전이 다른 5종의 진정제를 투여 한 후 측정된 모든 실험군의 SEF 95 값이 진정제 투여 전 상태와 비교하였을 때, 유의적으로 감소한다는 것을 확인하였다. 이상의 결과로 SEF 95의 정량적인 뇌파검사는 개에서 진정 상태를 평가하는 효과적인 방법이라고 생각된다.

Keywords

References

  1. Bergamasco L, Accatino A, Priano L, Neiger-Aeschbacher G, Cizinauskas S, Jaggy A. Quantitative electroencephalographic findings in beagles anaesthetized with propofol. Vet J 2003; 166: 58-66 https://doi.org/10.1016/S1090-0233(02)00254-X
  2. Bourin M, Briley M. Sedation, an unpleasant, undesirable and potentially dangerous side-effect of many psychotropic drugs. Hum Psychopharmacol 2004; 19: 135-139 https://doi.org/10.1002/hup.561
  3. Fassoulaki A, Paraskeva A, Patris K, Pourgiezi T, Kostopanagiotou G. Pressure applied on the extra I acupuncture point reduces bispectral index values and stress in volunteers. Anesth Analg 2003; 96: 885-890
  4. Feige B, Voderholzer U, Riemann D, Hohagen F, Berger M. Independent sleep EEG slow-wave and spindle band dynamics associated with 4 weeks of continuous application of short-half-life hypnotics in healthy subjects. Clin Neurophysiol 1999; 110: 1965-1974 https://doi.org/10.1016/S1388-2457(99)00147-9
  5. Heavner JE. Veterinary anesthesia update. J Am Vet Med Assoc 1983; 182: 30
  6. Herin RA, Purinton PT, Fletcher TF. Electroencephalography in the unanesthetized dog. Am J Vet Res 1968; 29: 329-336
  7. Itamoto K, Taura Y, Wada N, Taga A, Takuma T, Matsumura H, Miyara T. Effect of medetomidine on electroencephalography and use of a quantitative electroencephalograph for evaluating sedation levels in dogs. J Vet Med A Physiol Pathol Clin Med 2001; 48: 525-535 https://doi.org/10.1046/j.1439-0442.2001.00381.x
  8. Itamoto K, Taura Y, Wada N, Takuma T, Une S, Nakaichi M, Hikasa Y. Quantitative electroencephalography of medetomidine, medetomidine-midazolam and medetornidine-midazolambutorphanol in dogs. J Vet Med A Physiol Pathol Clin Med 2002; 49: 169-172 https://doi.org/10.1046/j.1439-0442.2002.00425.x
  9. Levy WJ, Shapiro HM, Maruchak G, Meathe E. Automated EEG processing for intraoperative monitoring: a comparison of techniques. Anesthesiology 1980; 53: 223-236 https://doi.org/10.1097/00000542-198009000-00009
  10. Litscher G. Effects of acupressure, manual acupuncture and Laser needle acupuncture on EEG bispectral index and spectral edge frequency in healthy volunteers. Eur J Anaesthesiol 2004; 21: 13-19
  11. Martin-Cancho MF, Lima JR, Luis L, Crisostomo V, Ezquerra LJ, Carrasco MS, Uson-Gargallo J. Bispectral index, spectral edge frequency 95%, and median frequency recorded for various concentrations of isoflurane and sevoflurane in pigs. Am J Vet Res 2003; 64: 866-873 https://doi.org/10.2460/ajvr.2003.64.866
  12. Muir WW, Mason D. Cardiovascular system. In: Lumb and Jones' Veterinary anesthesia, 3rd ed. Baltimore: Williams & Wilkins. 1996: 62-114
  13. Otto K, Short CE. Electroencephalographic power spectrum analysis as a monitor of anesthetic depth in horses. Vet Surg 1991; 20: 362-371 https://doi.org/10.1111/j.1532-950X.1991.tb01284.x
  14. Redding R, Knech C. Anestheics, sedatives, and neuromuscular blockers. In: Atlas of electroencephalography in the dog and cat, 1st ed. New York: Praeger. 1984: 199-242
  15. Redding R, Knech C. Seizure discharges and the electroencephalogram in organic disease of the CNS. In: Atlas of electroencephalography in the dog and cat, 1st ed. New York: Praeger. 1984: 244-330