Macromolecular Research

The Polymer Society of Korea (한국고분자학회)
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Surface Modification of Polyurethane Using Sulfonated PEG Grafted Polyrotaxane for Improved Biocompatibility

  • Park Hyung Dal (Dept. of Molecular Science and Technology, Ajou University) ;
  • Bae Jin Woo (Dept. of Molecular Science and Technology, Ajou University) ;
  • Park Ki Dong (Dept. of Molecular Science and Technology, Ajou University) ;
  • Ooya Tooru (School of Materials Science, Japan Advanced Institute of Science and Technology) ;
  • Yui Nobuhiko (School of Materials Science, Japan Advanced Institute of Science and Technology) ;
  • Jang Jun-Hyeog (Dept. of Biochemistry, College of Medicine, Inha University) ;
  • Han Dong Keun (Biomaterials Research Center, Korea Institute of Science and Technology) ;
  • Shin Jung-Woog (Dept. of Biomedical Engineering, Inje University)
  • Published : 2006.02.01
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Abstract

Sulfonated poly(ethylene glycol) (PEG-$SO_{3}$) grafted polyrotaxanes (PRx-PEG-$SO_{3}$) were prepared in order to utilize the unique properties of PEG-$SO_{3}$ and the supramolecular structure of PRx, in which PEG-$SO_{3}$ grafted $\alpha$-cyclodextrins ($\alpha$-CDs) were threaded onto PEG segments in a PEG-b-poly(propylene glycol) (PPG)-b-PEG triblock copolymer (Pluronic) chain capped with bulky end groups. Some of the PRx-PEG-$SO_{3}$ demonstrated a higher anticoagulant activity in case of PRx-PEG-$SO_{3}$ (P 105), and compared with the control they showed a lower fibrinogen adsorption in PRx-PEG-$SO_{3}$ (F68) and a higher binding affinity with fibroblast growth factor. The obtained results suggested that polyrotaxane incorporated with PEG-$SO_{3}$ may be applicable to the surface modification of clinically used polymers, especially for blood/cell compatible medical devices.

Keywords

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