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Surface Modification of Polyurethane Using Sulfonated PEG Grafted Polyrotaxane for Improved Biocompatibility  

Park Hyung Dal (Dept. of Molecular Science and Technology, Ajou University)
Bae Jin Woo (Dept. of Molecular Science and Technology, Ajou University)
Park Ki Dong (Dept. of Molecular Science and Technology, Ajou University)
Ooya Tooru (School of Materials Science, Japan Advanced Institute of Science and Technology)
Yui Nobuhiko (School of Materials Science, Japan Advanced Institute of Science and Technology)
Jang Jun-Hyeog (Dept. of Biochemistry, College of Medicine, Inha University)
Han Dong Keun (Biomaterials Research Center, Korea Institute of Science and Technology)
Shin Jung-Woog (Dept. of Biomedical Engineering, Inje University)
Publication Information
Macromolecular Research / v.14, no.1, 2006 , pp. 73-80 More about this Journal
Abstract
Sulfonated poly(ethylene glycol) (PEG-$SO_{3}$) grafted polyrotaxanes (PRx-PEG-$SO_{3}$) were prepared in order to utilize the unique properties of PEG-$SO_{3}$ and the supramolecular structure of PRx, in which PEG-$SO_{3}$ grafted $\alpha$-cyclodextrins ($\alpha$-CDs) were threaded onto PEG segments in a PEG-b-poly(propylene glycol) (PPG)-b-PEG triblock copolymer (Pluronic) chain capped with bulky end groups. Some of the PRx-PEG-$SO_{3}$ demonstrated a higher anticoagulant activity in case of PRx-PEG-$SO_{3}$ (P 105), and compared with the control they showed a lower fibrinogen adsorption in PRx-PEG-$SO_{3}$ (F68) and a higher binding affinity with fibroblast growth factor. The obtained results suggested that polyrotaxane incorporated with PEG-$SO_{3}$ may be applicable to the surface modification of clinically used polymers, especially for blood/cell compatible medical devices.
Keywords
polyrotaxane; sulfonated polyethylene glycol; anticoagulant activity; protein adsorption; biocompatible;
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