Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Association Study between Tic Disorder and Dopamine D2 Receptor Gene Polymorphism in Korean Population

틱장애와 도파민 D2 수용체 유전자와의 연합 연구

  • Lee, Soyoung Irene (Department of Psychiatry, College of Medicine Soonchunhyang University, Bucheon Hospital) ;
  • Cho, In Hee (Department of Psychiatry, Gachon University of Medicine and Science) ;
  • Kim, Seon Mee (Department of Family Medicine, College of Medicine Korea University, Guro Hospital) ;
  • Lee, Min-Soo (Department of Psychiatry, College of Medicine Korea University, Anam Hospital) ;
  • Jung, Han-Yong (Department of Psychiatry, College of Medicine Soonchunhyang University, Bucheon Hospital)
  • 이소영 (순천향대학교 의과대학 정신과학교실) ;
  • 조인희 (가천의과대학교 정신과학교실) ;
  • 김선미 (고려대학교 의과대학 가정의학교실) ;
  • 이민수 (고려대학교 의과대학 정신과학교실) ;
  • 정한용 (순천향대학교 의과대학 정신과학교실)
  • Published : 2006.11.30
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Abstract

Objectives : The purpose of the present study was to investigate whether the TaqI A polymorphism of dopamine receptor D2 gene(DRD2) is associated with Tourette syndrome(TS) and chronic motor tic disorder(CMT) in Korean population. Methods : DRD2 TaqI A RFLP genotyping was carried out with DNA extracted from blood samples of 75 patients with tic disorders(47 with TS and 28 with CMT) and 90 healthy subjects. Genotype and allelic frequencies for the DRD2 gene polymorphisms of the tic disorder group as a whole were compared to those of the control group. Separating the TS group, thereafter, the frequency of genotypes and alleles were compared to those of the controls. Results : The results demonstrated that genotype and allele distributions for the DRD2 gene polymorphism in the tic disorder as a whole, TS, and control groups were not significantly different. Conclusion : No association was found for DRD2 gene, TS and CMT. The data suggest that DRD2 gene may not be a useful marker for the prediction of the susceptibility of tic disorder.

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