Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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A case of Kikuchi's disease with skin involvement

일과성의 홍반성 피부병변을 동반한 소아 Kikuchi병 1례

  • Jang, Ji Min (Department of Pediatrics, College of Medicine, Korea University) ;
  • Woo, Chul Hee (Department of Pediatrics, College of Medicine, Korea University) ;
  • Choi, Jung Woo (Department of Pathology, College of Medicine, Korea University) ;
  • Song, DaeJin (Department of Pediatrics, College of Medicine, Korea University) ;
  • Yoo, Young (Department of Pediatrics, College of Medicine, Korea University) ;
  • Lee, Kwang Chul (Department of Pediatrics, College of Medicine, Korea University) ;
  • Son, Chang Sung (Department of Pediatrics, College of Medicine, Korea University)
  • 장지민 (고려대학교 의과대학 소아과학교실) ;
  • 우철희 (고려대학교 의과대학 소아과학교실) ;
  • 최정우 (고려대학교 의과대학 병리학교실) ;
  • 송대진 (고려대학교 의과대학 소아과학교실) ;
  • 유영 (고려대학교 의과대학 소아과학교실) ;
  • 이광철 (고려대학교 의과대학 소아과학교실) ;
  • 손창성 (고려대학교 의과대학 소아과학교실)
  • Received : 2005.08.12
  • Accepted : 2005.10.04
  • Published : 2006.01.15
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Abstract

Histiocytic necrotizing lymphadenitis, which is also commonly referred to as Kikuchi's disease (KD), is a self-limiting disease of unknown etiology. It affects individuals of all ages, although it is usually seen in young women. However, only a few descriptions of this disease are available in the pediatric literature. KD is clinically characterized by cervical lymphadenopathy, high fever, myalgia, neutropenia and, rarely, cutaneous eruptions. Cutaneous manifestations have been reported in 16-40 percent of KD cases. The specific skin changes occurring in cases of KD have yet to be completely characterized. In most of the reported cases thus far, the lesions have been located on the face and upper extremities. In this report, we describe a case of pediatric Kikuchi's disease, occurring in a 9-year-old boy. The boy exhibited transient erythematous maculopapular skin lesions over the entirety of his body, including his lower extremities.

Kikuchi병은 주로 젊은 여성에서 호발하고 소아에서는 비교적 드문 질환으로 원인 및 발생기전은 자세히 알려진 바 없으나 특별한 치료 없이도 수개월 이내에 자연적으로 회복되는 양성질환이다. 진단은 침범된 림프절의 특징적인 병리조직학적 소견을 확인하면 가능하다. 대부분의 환자에서 임상증상으로 림프절 비대와, 발열이 나타나고 피부증상은 16-40%에서 동반되며 주로 안면부, 상지, 상부 체간에 발생하고 대부분 작은 반점, 구진, 드물게 판과 결절 형태로 나타난다. 국내에서는 1983년 아급성 괴사성 임파선염이라는 이름으로 처음 언급한 이래 드물지 않게 보고되어왔으나 기존의 보고들은 피부증상을 동반하지 않거나 얼굴과 상지에 국한된 피부병변을 가진 증례 보고가 대부분이었다. 저자들은 지속적인 발열과 우측 경부 림프절 비대를 주소로 내원한 9세 남아에서 림프절의 조직검사결과 Kikuchi병을 진단할 수 있었고 이후 하지를 포함한 전신에 반점과 구진형태의 홍반성 병변이 발생한 Kikuchi병 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

Keywords

References

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