Effects of Cheunggak (Codium fragile) on lowering Lipid and Antioxidant

청각의 지질강하 및 항산화효과

  • Lee, Eun (College of Life science and natural Resources, Sang-ji University)
  • 이은 (상지대학교 생명자원과학대학)
  • Published : 2006.10.01

Abstract

Effects of Codium fragile ext. on lipid lowering and antioxidant activities were investigated in hyperlipidemic rat. Concentration of FFA and triglyceride in plasma showed a tendency to decrease in Codium fragile ext. groups. Concentration of plasma total cholesterol and LDL-cholesterol in Codium fragile ext. groupsshowed a low values than those of control group. However concentration of HDL-cholesterol showed no significant difference in all treatment groups. Concentration of liver total cholesterol and triglyceride showed a tendence to decrease in Codium fragile ext. groups. Concentration of plasma and liver TBARS showed a low values in Codium fragile ext. groups. The values of GSH-Px activity showed a tendency to increase in the Codium fragile ext. groups, However the values of SOD and CAT activity showed no significant difference in all treatment groups.

청각 추출액이 비만을 유도한 흰쥐의 지질강하 및 항산화효과에 미치는 영향을 검토했다. 각 처리군 별 유리지방산의 농도는 청각 처리군 모두가 대조군보다 낮은 값을 보였다. Triglyceride 량은 대조군과 비교하여 청각 처리군이 유의하게 낮은 값을 보였으며, 청각 첨가량이 증가함에 따라 하락했다. 혈액 내 total cholesterol 및 LDL-cholesterol농도는 청각 처리군 모두에서 감소하는 경향을 보였다. 그러나 HDL-cholesterol량은 대조군을 비롯하여 전 처리군에서 유의한 차이를 나타내지 않았다. 간장 내 total cholesterol과 triglyceride량은 청각 처리군 모두에서 하락하는 경향을 보여 정상군의 수준을 유지하였다. 혈장 및 간장의 TBARS 농도는 청각처리군 모두가 하락하는 경향을 보였으며, 정상군의 수준과 유사한 수치를 나타내었다. GSH-Px의 활성치는 청각 처리량이 증가함에 따라 증가하는 경향을 보여, 200mg/kg 처리군에서는 정상군의 활성치와 유의한 차이를 나타내지 않았다. 그러나 SOD 활성치는 청각처리에 관계없이 정상군을 비롯한 전 처리군에서 유의한 차이를 나타내지 않았다. 또한 CAT의 활성치는 청각 처리군에서 다소 증가하는 경향을 보였으나, 대조군과 유의한 차이를 나타내지는 않았다.

Keywords

References

  1. Bidlack W.R. and A.L. Tappel. 1973. Damage to microsomal membrane by lipid peroxidation. Lipids 8: 177-178 https://doi.org/10.1007/BF02544631
  2. Buege J.A. and S.D. Aust. 1978. Microsomal lipid peroxidation. In: Fleischer S, Packer Leds Methods in enzymelogy(London, Academic press) 52: 302-309 https://doi.org/10.1016/S0076-6879(78)52032-6
  3. Flohe L., R. Becker, R. Brigelius, E. Lengfelder. F. Otting. 1992. Convenient assays for superoxide dismutase. CRC Handbook of free radicals and antioxidants in Biomedicine pp. 287-293
  4. Hang A. and A.T. Hostmark. 1987. Lipoprotein lipases, lipoprotein and tissue lipids in rats fed fish oil or coconut oil. J Nutr. 117: 1011-1017 https://doi.org/10.1093/jn/117.6.1011
  5. Harris W.S., W.E. Connor and M.P. McMurry. 1983. The comparative reductions of the plasma lipids and lipoproteins by dietary polyunsaturated fats: salmon oil versus vegetable oils. Metabolism 32: 179-184 https://doi.org/10.1016/0026-0495(83)90226-3
  6. Ishikawa T. and M. Suzukawa . 1997. Effect of tea flavonoid supplementation on the susceptibility of low-density lipoprotein to oxidative modification. Am J Clin Nutr. 66(2): 261-266 https://doi.org/10.1093/ajcn/66.2.261
  7. Johnson L. H. and L.A. Hakan Borg. 1988. A spectrophtometric method for determination of catalaseactivity in small tissue samples. Analytical Biochemistry pp. 331-336
  8. Kang Y. H., T.Y. Ha and K.D. Moon. 1996. Effects of pine needle extracts on serum and liver lipid contents in rats fed high fat diet. J. Korean Soc. Food Nutr. 25: 367-373
  9. Kasuga, M. 1997. Molecular biology of adipocytes and obesity (Symposium). Saishin Igaku 52: 1063-1064
  10. Langanier S and B.P. Yu. 1987. Anti-lipoperoxidation action of food restriction. Biochem. Biophys Res. Comm. 145: 1185- 1202 https://doi.org/10.1016/0006-291X(87)91562-2
  11. Lee E., M.Y. Choi and H.S. Oh. 2000. Effects of Powdered Siho (Bupleuri Radix) on serum and liver lipid composition and Antioxidative capacity in rat fed high oxidized fat. Korean J. Nutrition 33(5): 502-506
  12. Lee E. 2003. Effects of powdered pine needle (Pinus densiflora seib et Zucc.) on serum and Liver Lipid Composition and Antioxidative, J. Korean Soc. Food Sci. Nutr. 32(6): 926-930 https://doi.org/10.3746/jkfn.2003.32.6.926
  13. Levander, O.A., D. PDeLoach, C. Morris and P.B. Moser. 1983. Platelet glutathione peroxidase activity as an index of selenium status in rats. J. Nutr. 113: 55-63 https://doi.org/10.1093/jn/113.1.55
  14. Masugi, J. 1997. Molecular biology of adipocytes and obesity (Symposium). Saishin Igaku 52: 1065-1069
  15. Ohkawa H., N. Ohishi and K. Yagi. 1979. Assay for lipid peroxide in animal tissues by thiobarbituric acid reaction. Anal Biochem 95: 351-358 https://doi.org/10.1016/0003-2697(79)90738-3
  16. Saito M. 1988. Interaction between lipid peroxide formation and nutritional status. J. JPN Soc. Nutr. Food Sci. 41: 343-349 https://doi.org/10.4327/jsnfs.41.343
  17. Sanders T.A.B. and M.C. Hochland. 1983. A comparison of the influence of on plasma lipids and platelet function of supplements of n-3 and polyunsaturated fatty acid. Brit J. Nutr. 50: 521-529 https://doi.org/10.1079/BJN19830123
  18. Sin M. K. and G.J. Han. 1997. The effects of green tea on the serum lipid and liver tissue of cholesterol fed rats. Korean J. Sci. Technol. 29: 1255-1263
  19. Ueda, H. and K. Tanoue. 2000. Growth-depressing and cholesterol- lowering effects of quillaja and tea saponins in chicks as influenced by diet composition. Anim. Sci. J. 71(4): 393-399
  20. Vergroeson A.T. 1997. Physiological effects of dietary linoleic acid. Nutr. Rev. 35: 1-9
  21. 홍문화,장원,김완희,어일랑,남현철,박수일,구본홍,박인규,안규십, 박병렬. 1995. 동의대보감. 고려문화사 pp. 1718
  22. 현영희, 구본순, 송주은, 김덕숙. 2004. 형설출판사. 식품재료학 pp. 325