Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Anti-inflammatory Effect of Aloe Vera and Aloe Arborescens in Phosphatidic Acid-stimulated Raw Cells

Phosphatidic acid로 유도된 Raw cell에서 알로에 베라 및 알로에 센스의 염증 억제 효과

  • 조영제 (상주대학교 식품공학과) ;
  • 안봉전 (대구한의대학교 화장품약리학과) ;
  • 김명욱 ((주)김정문알로에 과학연구소) ;
  • 심창섭 ((주)김정문알로에 과학연구소)
  • Published : 2006.03.31
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Abstract

With extracted Aloe vera and Aloe arborescens, anti-inflammatory effect was examined in phosphatidic acid-stimulated Raw 264.7 cells. Phosphatidic acid $(50\;{\mu}g/ml)$ treatment increased inflammation related 264.7 cells. The extracts of $80\;{\mu}g/ml$ concentration from Aloe arborescens reduced the expression of iNOS. Aloe vera and Aloe arborescens also reduced the expression of COX-2, it seems that anti-inflammatory effects of Aloe extracts is partly due to the inhibition of COX-2 expression by inhibiting in Raw 264.7 cells.

알로에 베라와 알로에 센스 추출물에 의한 phosphatidic acid(PA)로 염증을 유발한 Raw 264.7 세포에서 항염증 효과를 측정하였다. 알로에 자체는 염증반응에 관여하지 않았으며, 알로에 추출물들이 PA처리에 의해 증가된 염증관련 COX-2의 발현을 억제함으로서 항염증 효과가 있음이 확인되었다.

Keywords

References

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