Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Kochiae Fructus Extracts on the Expression of Angiogeneis and Inflammation Related Proteins

지부자(地膚子)의 신생혈관 및 염증매개 단백질 발현에 미치는 영향

  • Na, Sang-Hyuk (Department of Preventive Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Shin, Yong-Cheol (Department of Preventive Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Ko, Seong-Gyu (Department of Preventive Medicine, College of Oriental Medicine, Kyunghee University)
  • 나상혁 (경희대학교 한의과대학 예방의학교실) ;
  • 신용철 (경희대학교 한의과대학 예방의학교실) ;
  • 고성규 (경희대학교 한의과대학 예방의학교실)
  • Published : 2006.06.25
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Abstract

Hypoxia induced angiogenesis and inflammation are essential processes for metastasis and progress of solid tumors. We examined the anti-angiogenic and inflammation related activity of Kochiae Fructus (KF) extract. To investigate the roles of the KF extract, we performed MTS assay, western blots using HaCaT cells and $HepG_2$ cells. The results are as follows. The protein level of $HIF-1{\alpha}$ was reduced when induced by $CoCl_2$ in $HepG_2$ cells treated with KF extract and induced by IGF-11 in HaCaT cells treated with KF extract. KF extract reduced the mRNA level of VEGF in HaCaT cells and KF extract reduced the protein level of iNOS in HaCaT cells. These results suggest that KF extract contributes to the anti-angiogenic and anti-inflammatory activities and also we could assume that KF extract act as antioxidant or anti-inflammatory agents via reduction of $HIF-1{\alpha}$.

Keywords

References

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