Journal of Acupuncture Research
- Volume 22 Issue 1
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- Pages.155-164
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- 2005
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- 2586-288X(pISSN)
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- 2586-2898(eISSN)
Effect of Pinelliae Rhizoma Herbal Acupuncture on the Release of Thymus and Activation-Regulated Chemokine(TARC) in Human Bronchial Epithelial Cell
반하(半夏) 약침액(藥鍼液)이 사람 기관지 상피세포의 TARC 분비에 미치는 효과
- Hong, Jae-hwa (Department of Acupuncture & Moxibustion, College of Oriental Medicine Daegu Haany University) ;
- Seo, Jung-chul (Department of Acupuncture & Moxibustion, College of Oriental Medicine Daegu Haany University) ;
- Lim, Seong-chul (Department of Acupuncture & Moxibustion, College of Oriental Medicine Daegu Haany University) ;
- Jung, Tae-young (Department of Acupuncture & Moxibustion, College of Oriental Medicine Daegu Haany University) ;
- Han, Sang-won (Department of Acupuncture & Moxibustion, College of Oriental Medicine Daegu Haany University)
- 홍재화 (대구한의대학교 한의과대학 침구학교실) ;
- 서정철 (대구한의대학교 한의과대학 침구학교실) ;
- 임성철 (대구한의대학교 한의과대학 침구학교실) ;
- 정태영 (대구한의대학교 한의과대학 침구학교실) ;
- 한상원 (대구한의대학교 한의과대학 침구학교실)
- Received : 2005.01.18
- Accepted : 2005.01.27
- Published : 2005.02.20
Abstract
Objective : Chemokines are important for the recruitment of leukocytes, which is essential in host defense to the sites of infection. The thymus and activation-regulated chemokine (TARC) is a CC chemokine which potentially plays a role via a paracrine mechanism in the development of allergic respiratory diseases. Methods : The objective of this study is to investigate the effect of Pinelliae Rhizoma Herbal Acupuncture Solution (PHS) on the secretion of TARC of human bronchial epithelial cell. Methods : Enzyme-linked immunosorbent assay (ELISA) was performed to detect the secretion of TARC. The cytotoxicity was measured by MTT assay. Results : PHS significantly inhibited the secretion of TARC with a dose-dependant manner. The effective dosage did not have the cytotoxicity on human bronchial epithelial cell by MTT assay. Conclusion : Results of our study imply that PHS would play an important role in modulation of TARC in Human bronchial epithelial cells.
사람 기관지 상피세포에 알러지 환경을 유발 하고자 사이토카인을 처리하여 TARC의 분비를 유도하고, 이 케모카인 분비에 반하(半夏) 약쇄액(藥鎖液)이 미치는 효과를 실험한 결과 다음과 같은 결론을 얻었다. 1. 사람의 기관지 상피 세포주에 각각 IL-4, TNF-
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