Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)
- Volume 19 Issue 5
- /
- Pages.1251-1255
- /
- 2005
- /
- 1738-7698(pISSN)
- /
- 2288-2529(eISSN)
Effect of Bee Venom Acupuncture on the Recovery of Chondrocyte Phenotype in Rabbit Cartilage
봉독약침이 연골세포 활성에 미치는 영향
- Zhao Mei-Ai (Department of Oriental Medicine Science, Graduate School of East-West Medial Science, Kyung-Hee University) ;
- Lee Seung-Ki (Department of Oriental Medicine Science, Graduate School of East-West Medial Science, Kyung-Hee University) ;
- Kim Gun-Ho (Department of Oriental Medicine Science, Graduate School of East-West Medial Science, Kyung-Hee University) ;
-
Choi Sun-Mi
(Department of Medical Research, Korea Institute of Oriental Medicine)
;
-
Shim In-Sop
(Department of Integrative Medicine, College of Medicine, The Catholic University of Korea)
;
- Kang Sung-Keel (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung-Hee University) ;
-
Lee Hye-Jung
(Department of Oriental Medicine Science, Graduate School of East-West Medial Science, Kyung-Hee University)
;
-
Hahm Dae-Hyun
(Department of Oriental Medicine Science, Graduate School of East-West Medial Science, Kyung-Hee University)
- 조미애 (경희대학교 동서의학대학원 침구경락학교실) ;
- 이승기 (경희대학교 동서의학대학원 침구경락학교실) ;
- 김건호 (경희대학교 동서의학대학원 침구경락학교실) ;
-
최선미
(한국한의학연구원 의료연구부)
;
-
심인섭
(가톨릭대학교 의과대학 통합의학교실)
;
- 강성길 (경희대학교 경희의료원 한방병원 침구과) ;
-
이혜정
(경희대학교 동서의학대학원 침구경락학교실)
;
-
함대현
(경희대학교 동서의학대학원 침구경락학교실)
- Published : 2005.10.01
Abstract
Articular cartilage is an important factor for studying the arthritic diseases. The chondrocyte isolated from cartilage has the characieristic of differentiation and rf-differentiation when cultured in monolayer The bee venom (BV) acupuncture was investigated to examine their abilities on chondrocyte re-differentiation via rabbit chondrocyte primary culture. And the expression profiles of type II collagen (COL2) was analyzed using RT-PCR and western hybridization at third passage chondrocyte. In general, the mRNA expression of type II collagen was reduced step by step with the subculture of the chondrocyte. However, after the BV treatment for 48hr at third passage, the expressions of type II collagen were found to be significantly up-regulated, the same result was confirmed by western blotting. These results suggested that the diluted solution of BV for herb-acupuncture was very effective on the recovery of articular chondrocyte phenotype.