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Effect of Bee Venom Acupuncture on the Recovery of Chondrocyte Phenotype in Rabbit Cartilage  

Zhao Mei-Ai (Department of Oriental Medicine Science, Graduate School of East-West Medial Science, Kyung-Hee University)
Lee Seung-Ki (Department of Oriental Medicine Science, Graduate School of East-West Medial Science, Kyung-Hee University)
Kim Gun-Ho (Department of Oriental Medicine Science, Graduate School of East-West Medial Science, Kyung-Hee University)
Choi Sun-Mi (Department of Medical Research, Korea Institute of Oriental Medicine)
Shim In-Sop (Department of Integrative Medicine, College of Medicine, The Catholic University of Korea)
Kang Sung-Keel (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung-Hee University)
Lee Hye-Jung (Department of Oriental Medicine Science, Graduate School of East-West Medial Science, Kyung-Hee University)
Hahm Dae-Hyun (Department of Oriental Medicine Science, Graduate School of East-West Medial Science, Kyung-Hee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.19, no.5, 2005 , pp. 1251-1255 More about this Journal
Abstract
Articular cartilage is an important factor for studying the arthritic diseases. The chondrocyte isolated from cartilage has the characieristic of differentiation and rf-differentiation when cultured in monolayer The bee venom (BV) acupuncture was investigated to examine their abilities on chondrocyte re-differentiation via rabbit chondrocyte primary culture. And the expression profiles of type II collagen (COL2) was analyzed using RT-PCR and western hybridization at third passage chondrocyte. In general, the mRNA expression of type II collagen was reduced step by step with the subculture of the chondrocyte. However, after the BV treatment for 48hr at third passage, the expressions of type II collagen were found to be significantly up-regulated, the same result was confirmed by western blotting. These results suggested that the diluted solution of BV for herb-acupuncture was very effective on the recovery of articular chondrocyte phenotype.
Keywords
chondrocyte; cartilage; bee venom; type II collagen; herb-acupuncture; rabbit;
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