Effects of Deer Horn Extract on the Experimental Asthma Induced by Ovalbumin

녹용 물추출물이 Ovalbumin으로 유도된 천식동물모델에 미치는 영향

  • Park Ki-Bum (College of Oriental Medicine, Daegu Haany University) ;
  • Byun Sung-Hui (College of Oriental Medicine, Daegu Haany University, Research Center for Biomedical Resources of Oriental Medicine) ;
  • Yang Chae-Ha (College of Oriental Medicine, Daegu Haany University, Research Center for Biomedical Resources of Oriental Medicine) ;
  • Seo Jung-Chul (College of Oriental Medicine, Daegu Haany University, Research Center for Biomedical Resources of Oriental Medicine) ;
  • Byun Joon-Seok (College of Oriental Medicine, Daegu Haany University) ;
  • Him Sang-Chan (College of Oriental Medicine, Daegu Haany University, Research Center for Biomedical Resources of Oriental Medicine)
  • 박기범 (대구한의대학교 한의과대학) ;
  • 변성희 (대구한의대학교 한의과대학, 한방생명자원연구센터) ;
  • 양재하 (대구한의대학교 한의과대학, 한방생명자원연구센터) ;
  • 서정철 (대구한의대학교 한의과대학, 한방생명자원연구센터) ;
  • 변준석 (대구한의대학교 한의과대학) ;
  • 김상찬 (대구한의대학교 한의과대학, 한방생명자원연구센터)
  • Published : 2005.10.01

Abstract

This study was performed to investigate the effect of oral administration of deer horn against the asthma. Deer horn improves body metabolism and strengthens overall health, especially in elderly persons and young children. Additionally, it stimulates sexual function in females and can stimulate wound healing. Asthma was induced to Balblc mouse by i.p. injection and aerosol immunization with ovalbumin. It was observed the change of the eosinophil number in the BALF. Concentrations of IL-4, IL-5 in BALF and splenocyte were assessed by ELISA, IgG and IgE from serum were calculated by same method. The number of eosinophil in BALF was not significantly changed in deer horn group compared with control group. Concentration of IL-4 in BALF was significantly decreased in deer horn group compared with control group. Levels of IL-5 from BALF and splenocyte were significantly decreased in deer horn group compared with control group, respectively. Concentrations of IgE and IgG in serum were significantly decreased in deer horn group compared with control group, separately. We found that the effect of deer horn extract in asthma was implicated in reductions of IL-4, IL-5 released from Th2 cell, and decreases of IgG, IgE from plasma cell. These findings suggest that deer horn extract can produce anti-asthmatic effect, which may play a role in allergen-induced asthma therapy.

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