Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Boiled-Water Extract from Hizikia fusiformis Showing Antioxidant Effects

  • Jang, Mi-Soon (Biotechonology Research Center, National Fisheries Research & Development Institute) ;
  • Kim, Ji-Young (Biotechonology Research Center, National Fisheries Research & Development Institute) ;
  • Lim, Chi-Won (Biotechonology Research Center, National Fisheries Research & Development Institute) ;
  • Kim, Yeon-Kye (Biotechonology Research Center, National Fisheries Research & Development Institute) ;
  • Park, Hee-Yeon (Biotechonology Research Center, National Fisheries Research & Development Institute)
  • Published : 2005.12.31
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Abstract

Boiled-water extract (BWE) of Hizikia fusiformis has antioxidant effects. To investigate antioxidant effects of BWE, 1,1-dephenyl-2-picrylhydrazyl (DPPH) and thiobarbituric acid (TBA) methods were used. BWE exhibited strong radical-scavenging activity (87.3% at final conc. $2000\;{\mu}g$ BWE/ml in an assay mixture) on DPPH and good inhibitory activity (64% at final conc. $1000\;{\mu}g$ BWE/ml in an assay mixture) on lipid peroxidation. Raw 264.7 cells treated with lipopolysaccharide (LPS) showed 26.7-fold increase in nitric oxide (NO) ($48.9\;{\mu}M$) compared with control group ($1.83\;{\mu}M$). When treated with BWE and LPS, NO production was inhibited by BWE dose-dependently.

Keywords

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