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Boiled-Water Extract from Hizikia fusiformis Showing Antioxidant Effects  

Jang, Mi-Soon (Biotechonology Research Center, National Fisheries Research & Development Institute)
Kim, Ji-Young (Biotechonology Research Center, National Fisheries Research & Development Institute)
Lim, Chi-Won (Biotechonology Research Center, National Fisheries Research & Development Institute)
Kim, Yeon-Kye (Biotechonology Research Center, National Fisheries Research & Development Institute)
Park, Hee-Yeon (Biotechonology Research Center, National Fisheries Research & Development Institute)
Publication Information
Journal of Applied Biological Chemistry / v.48, no.4, 2005 , pp. 202-206 More about this Journal
Abstract
Boiled-water extract (BWE) of Hizikia fusiformis has antioxidant effects. To investigate antioxidant effects of BWE, 1,1-dephenyl-2-picrylhydrazyl (DPPH) and thiobarbituric acid (TBA) methods were used. BWE exhibited strong radical-scavenging activity (87.3% at final conc. $2000\;{\mu}g$ BWE/ml in an assay mixture) on DPPH and good inhibitory activity (64% at final conc. $1000\;{\mu}g$ BWE/ml in an assay mixture) on lipid peroxidation. Raw 264.7 cells treated with lipopolysaccharide (LPS) showed 26.7-fold increase in nitric oxide (NO) ($48.9\;{\mu}M$) compared with control group ($1.83\;{\mu}M$). When treated with BWE and LPS, NO production was inhibited by BWE dose-dependently.
Keywords
Hizikia fusiformis; DPPH; TBA; NO; antioxidant;
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