대한의생명과학회지 (Biomedical Science Letters)
- 제11권3호
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- Pages.343-347
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- 2005
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
Effect of Bambusae caulis in Liquamen on Streptozocin-Induced Diabetic C57BL/6 Mice
- Deung Young-Kun (Department of Basic Science and Institute of Basic Medical Science, Wonju College of Medicine, Yonsei University) ;
- Park Seung-Kyu (Department of Parasitology, Wonju College of Medicine, Yonsei University) ;
- Jin Dan (Department of Microbiology, Wonju College of Medicine, Yonsei University) ;
- Yang Eun-Ju (Department of Biomedical Laboratory Science and Institute of Health Science, College of Health Science, Yonsei University) ;
- Lim Soo-Jung (Department of Biomedical Laboratory Science and Institute of Health Science, College of Health Science, Yonsei University) ;
- Kwon Ki-Rok (Department of Acupuncture, College of Oriental Medicine, Sangji University) ;
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Kim Dong-Heui
(Department of Basic Science and Institute of Basic Medical Science, Wonju College of Medicine, Yonsei University) ;
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Lee Kyu-Jae
(Department of Parasitology, Wonju College of Medicine, Yonsei University)
- 발행 : 2005.09.01
초록
Bambusae caulis in Liquamen is one of the important herbal medicine produced by heating bamboo indirectly and is used for treatment of stroke, hypertension, and diabetes etc. Recently the mechanism of clinical effects on Bambusae caulis in Liquamen has been studied. This experiment was conducted to confirm the clinical effects of Bambusae caulis in Liquamen on type 1 diabetes and its related mechanism. We divided C57BL/6 mice into 3 groups and induced them to be type 1 diabetes by injection of streptozocin into peritoneum. The dosage of each group was 150 mg/kg once only, 140 mg/kg once only and 40 mg/kg for 5 days respectively. The two groups injected streptozocin for once took orally Bambusae caulis in Liquamen after the induction of diabetes, and the other one group was given Bambusae caulis in Liquamen during the diabetes inducing period. As the result, the two diabetes-induced groups showed blood glucose decreasing effect by Bambusae caulis in Liquamen on an average, but they didn't show the signiftcant differences statistically. But Bambusae caulis in Liquamen showed the anti-diabetic effect suppressing blood sugar rising trend during the diabetes inducing peried (P<0.05). The anti-oxidative effect of Bambusae caulis in Liquamen was measured with the hypoxanthine/xanthine oxidase (HX/XOD) system. The quantity of ROS was measured using DCFDA reagent indirectly. As the result,