대한의생명과학회지 (Biomedical Science Letters)
- 제11권3호
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- Pages.337-341
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- 2005
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
Cytotoxic Effect of Syringic Acid on Human Oral Epithelioid Carcinoma Cells
- Lee Joo-Hyun (College of Dental Medicine, Wonkwang University) ;
- Han Du-Suk (College of Dental Medicine, Wonkwang University) ;
- Jekal Seung-Joo (Wonkwang Health Science College) ;
- Lee Jae-Hyung (Wonkwang Health Science College) ;
- Kim Chong-Ho (Wonkwang Health Science College) ;
- Yoo Min (Department of Biology, Keimyung University) ;
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Park Seung-Taeck
(School of Medicine, Wonkwang University)
- 발행 : 2005.09.01
초록
This study was undertaken to clerify the cytotoxic effect of syringic acid by colorimetric assay on human cancer cells. For the evaluation of cytotoxicity of syringic acid, the cell viability and cell adhesion activity of syringic acid on cancer cells, human oral epithelioid carcinoma cells were determined using by colorimetric assays such as MTT (3-[4,5dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay and XTT (2,3-bis-[2-methoxy-4-nitro-5-sulfophenyl]2H-tetrazolium-5-caboxanilide) assay, respectively after human oral epithelioid carcinoma cells were treated with syringic acid for 48 hours. In this study, the cell viability of syringic acid on human oral epithelioid carcinoma cells showed a significant decrease by MTT assay compared with control, and also, the cell adhesion activity by XTT assay was decreased significantly in these cells after cells were treated with various concentrations of syringic acid for 48 hours.