Antifungal Activity of Chlororinated Bibenzyl Compound on the Dermatophytic Fungus Trichophyton mentagrophytes

  • Na, Young-Soon (Department of Beauty, Konyang University) ;
  • Kim, Hoon (Department of Beauty, Konyang University) ;
  • Oh, Hyun-Ju (Department of Herbal Resources, Professional Graduate School of Oriental Medicine and Institute of Basic Natural Sciences Wonkwang University) ;
  • Kim, Myung-Ju (Department of Skin & Beauty, Kwangju Health Science College) ;
  • Baek, Seung-Hwa (Department of Herbal Resources, Professional Graduate School of Oriental Medicine and Institute of Basic Natural Sciences Wonkwang University)
  • Published : 2005.08.01

Abstract

The chlororinated bibenzyl compound (1) inhibited the growth of the Gram positive bacterium Bacillus subtilis ATCC 19659, (2mm inhibition zone at $30{\mu}g/disc$), Candida albicans ATCC 14053, (2mm inhibition zone at $30{\mu}g/disc$), and the dermatophytic fungus Trichophyon mentagrophtes ATCC 28185, (3mm inhibition zone at $30{\mu}g/disc$).

Keywords

References

  1. Schofield, W.B. Introduction to Bryology MacMillan Publishing Copy: New York, 1985.
  2. Asakawa, Y. In progress in the Chemistry of Organic Natural Products ; Herz, W., Kirby, G.W., Moore, R.E., Steglich, W., Tamm, C. Eds. ; Springer Vienma, Vol. 65, 1-525, 1995.
  3. Zinsmeister, H.D., Becker, H., Eicher, T. Bryophytes, a Source of Biologically Active, Naturally Occurring Material? Angew Chem Int Ed 30, 130-147, 1991.
  4. Asakawa, Y. Recent advances in phytochemistry of bryophytes-acetogenins, terpenoids and bis(bibenzyl)s from selected Japanese, Taiwanese, New Zealand, Argentinean and European liverworts. Phytochemistry 56, 297-312, 2001.
  5. New Zealand Plant Names Database. http://nzflora.landcareresearch.co.nz/ Landcare Research, New Zealand: 2000; accessed 14 August 2003.
  6. Allison, KW., Child, J. The Liverworts of New Zealand; University of Otago Press: Dunedin, 1975.
  7. Perry, N.B., Foster, L.M. Sesquiterpenejquinol from a New Zealand liverwort, Riccardia crassa. J Nat Prod 58, 1131-1135, 1995.
  8. Toyota, M., Asakawa, Y. Sesquiterpene derivatives and a norsesquiterpenoid from the liverworts Riccardia crassa and Porella caespitans. Phytochemistry 32, 137-140, 1990.
  9. Benesova, V., Samek, Z., Herout, V., Sorm, F. Plant substances. XXIX. Isolation and structure of two new indole alkaloids from Riccardia sinuata. Collect Czech Chem Commun 34, 1807-1809, 1969.
  10. Benesova, V., Herout. V., Sorm, F. Plant substances. XXX. Components of liverworts Aneura pinguis, Riccardia sinuata, R. incuroaia, and Conocephalum conicum. Collect Czech Chem Commun 34, 1810-1814, 1969.
  11. Asakawa, Y., Toyota, M., Matsuda, R, Takikawa, K., Takemoto, T. Chemosystematics of bryophytes. Part 15. Distribution of novel cyclic bisbibenzyls in Marchantia and Riccardia species. Phytochemistry 22, 1413-1415, 1983.
  12. Asakawa, Y., Toyota, M., Taira, Z., Takemoto, T., Kido, M., S. Gray. Riccardin A and riccardia B two novel cyclic bis(bibenzyls) possessing cytotoxicity from the liverwort Riccardia muItifida (L.) J Org Chem 48, 2164-2167, 1983. https://doi.org/10.1021/jo00161a009
  13. Dienes, Z., Nogradi, M., Vermes, B., Kajtar-Peredy, M. Synthesis of marchantin I, a macrocyclic bis(bibenzyl ether) from Riccardia multifida. Liebigs Ann Chem 1141-1143, 1989.
  14. Kurata, K., Amiya, T. A new bromophenol from the red alga Polysiphonia urceolata. Bull Chem Soc Jpn 53, 2020-2022, 1980.
  15. Toyota, M., Shimarnura, T., Ishii, H., Renner, M., Braggins, L Asakawa, Y. New bibenzyl cannabinoid from the New Zealand liverwort Radula marginata. Chem. Pharm. Bull. 50, 1390-1392, 2002.
  16. Lorimer, S.D., Barns, G., Evans, A.C, Foster, L.M., May, B.CH., Perry, N.B., Tangney, RS. Cytotoxicity and antimicrobial activity of plants from New Zealand's subantarctic islands. Phytomed. 2, 327-333, 1996.
  17. Schroeder, A.C, Hughes, R.G. Jr., Bloch, A.: Synthesis and biological effects of acyclic pyrimidine nucleoside analogues. J Med Chem 24, 1078-1083, 1981.
  18. Baek, S.H., Lim, J.A., Kwag, J.S., Lee, H.O., Chun, H.J., Lee, J.H., Perry, N.B. Screening for biological activity of crude extract and bioactive fractions from Brochyglottis monroi. Kor J Orien Physiol & Pathol 17(3):826-828, 2003.
  19. Sirirath, S., Tanaka, J., Ohtani, I.I., Ichiba, T., Rachmat, R., Ueda, K., Usui, T., Osada, H., Higa, T. Bitungolides A-F, new polyketides from the Indonesian sponge Theonella d. swinhoei. J. Nat. Prod. 65, 1820-1823, 2002.
  20. Speicher, A., Heisel, R, Kolz, J. First detection of a chloroperoxidase in bryophytes. Phytochem. 62, 679-682, 2003.