Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Gamgung-tang on Fas-mediated Apoptosis in Human Thyrocytes

감궁탕이 사람의 갑상선세포에서 Fas 매개성 apoptosis에 미치는 영향

  • Nam Kyung Soo (Intractable Disease Research Center and Department of Pharmacology, College of Medicine, Dongguk University) ;
  • Son Ok Lye (Intractable Disease Research Center and Department of Pharmacology, College of Medicine, Dongguk University) ;
  • Kim Mee Kyung (Intractable Disease Research Center and Department of Pharmacology, College of Medicine, Dongguk University) ;
  • Kim Cheorl Ho (Department of Biochemistry and Molecular Biology, College of Oriental Medicine, Dongguk University) ;
  • So Myung Suk (Department of Nursing, Daegu Health College) ;
  • Jeon Byung Hun (Department of Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Shon Yun Hee (Intractable Disease Research Center and Department of Pharmacology, College of Medicine, Dongguk University)
  • 남경수 (동국대학교 난치병한양방치료연구소 및 의과대학 약리학교실) ;
  • 손옥례 (동국대학교 난치병한양방치료연구소 및 의과대학 약리학교실) ;
  • 김미경 (동국대학교 난치병한양방치료연구소 및 의과대학 약리학교실) ;
  • 김철호 (동국대학교 한의과대학 생화학분자생물학교실) ;
  • 소명숙 (대구보건대학 간호학과) ;
  • 전병훈 (원광대학교 한의과대학 병리학교실) ;
  • 손윤희 (동국대학교 난치병한양방치료연구소 및 의과대학 약리학교실)
  • Published : 2005.08.01
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Abstract

Inflammatory cytokine, abundantly produced in Hashimoto's thyroiditis, induced Fas expression in normal thyrocytes. We determined that susceptibility to Fas-activated apoptosis could be influenced by inflammatory cytokine and investigated a potential role of Gamgung-tang (GGT, Glycyrrhizae Radix, black beans, Angelicae Radix and Cnidii Rhizoma) in the thyroid follicular cells. $IL-1\beta$ was able to induce Fas expression in normal thyrocytes. GGT inhibited $IL-1\beta-induced$ Fas expression. Thyroid follicular cells were found to undergo DNA fragmentation with the inflammatory cytokines. GGT inhibited DNA fragmentation in a dose-dependent manner. These results suggest that GGT inhibit Fas-mediated apoptosis in thyroid follicular cells, therefore, may have therapeutic potential in the treatment of autoimmune chronic thyroiditis.

Keywords

References

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