YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Preparation and Evaluation of Paclitaxel Nano-particle Delivery System for Parenteral Formulations

나노입자수송시스템을 이용한 파클리탁셀 정맥주사제의 제조 및 평가

  • Jeon Il-Soon (College of Pharmacy, Chungnam National University) ;
  • Kim Jeong-Soo (College of Pharmacy, Chungnam National University) ;
  • Lee Gye-Won (Department of Pharmaceutical Engineering, Konyang University) ;
  • Jee Ung-Kil (College of Pharmacy, Chungnam National University)
  • Published : 2005.08.01
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Abstract

Paclitaxel is an effective antineoplastic agent against ovarian, colon and breast tumors. But there have been many difficulties to formulate this drug due to the extremely low aqueous solubility. Paclitaxel is currently formulated in a vehicle composed of Cremophor EL and absolute ethanol mixture which is $5\~20$ fold diluted in normal saline or $5\%$ dextrose solution before I.V. injection. However, this formulation has many problems such as allergic reactions and drug precipitation on aqueous dilution. To overcome these problems, we prepared the micelle and microemulsion systems for parenteral administration of paclitaxel by using glycofurol, $Soluto^{(R)}lHS$ 15 and oleic acid. Phase diagram, pH-rate stability, particle size distributions and pharmacokinetics of the systems were studied. Micelles and microemulsions formulated as nano-particle delivery system were physically and chemically stable. Therefore, these formulations might be the promising alternative candidate for the parenteral delivery of paclitaxel.

Keywords

References

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