Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Uterotrophic and Hershberger Assay for Butyl ρ-Hydroxybenzoic Acid

  • Ahn, Ji-Yun (Food Function Research Civision, Korea Food Research Institute) ;
  • Kim, Sung-Ran (Food Function Research Civision, Korea Food Research Institute) ;
  • Ha, Tae-Youl (Food Function Research Civision, Korea Food Research Institute) ;
  • Kim, Sung-Su (Food Function Research Civision, Korea Food Research Institute) ;
  • Han, Chan-Kyu (Food Function Research Civision, Korea Food Research Institute)
  • Published : 2005.06.01
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Abstract

Butyl $\rho$-hydroxybenzoic acid (butyl paraben, BP) is a homologous series of parabens and is widely used as a preservative in cosmetic and pharmaceutical products. The purpose of this study was to investigate the estrogenic/antiandrogenic activities of BP in animals. For that, we performed an uterotrophic assay and a Hershberger assay in rats. In uterotrophic assay, BP was administered subcutaneously to immature female SD rats (18 days old) for 3 consecutive days. The wet and dry uterus weights were significantly increased in the groups treated with BP in dose­dependent manner. In case of Hershberger assay, BP significantly reduced the weight of seminal vesicle of castrated rats. And other accessory organ/glands - prostate, Cowper's glands, bulbocavernosus muscle and glans penis were also slightly decreased. The results of this study suggested that BP showed estrogenic and anti-androgenic activities in vivo.

Keywords

References

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