Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Studies on the Reproductive Toxicant and Blood Metabolite in Pups Born After Bisphenol A Administration in Pregnant Mice

임신중인 생쥐에 Bisphenol A 투여 후 태어난 차산자의 생식독성과 혈액성분에 관한 연구

  • Park Dong-Heon (College of Animal Resource Science, Kangwon National University) ;
  • Jang Hyun-Yong (College of Animal Resource Science, Kangwon National University) ;
  • Kim Choung-Ik (College of Animal Resource Science, Kangwon National University) ;
  • Cheong Hee-Tae (College of Animal Resource Science, Kangwon National University) ;
  • Park Choon-Keun (College of Animal Resource Science, Kangwon National University) ;
  • Yang Boo-Keun (College of Animal Resource Science, Kangwon National University)
  • 박동헌 (강원대학교 동물자원과학대학) ;
  • 장현용 (강원대학교 동물자원과학대학) ;
  • 김정익 (강원대학교 동물자원과학대학) ;
  • 정희태 (강원대학교 동물자원과학대학) ;
  • 박춘근 (강원대학교 동물자원과학대학) ;
  • 양부근 (강원대학교 동물자원과학대학)
  • Published : 2005.06.01
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Abstract

Bisphenol A (BPA) is a monomer used in the manufacture of a multitude of chemical products, including epoxy resins and polycarbonate. The objective of this study was to evaluate the effects of BPA administration on reproductive characteristics and blood hematological and chemical values in offspring of pregnant dams treated with BPA. BPA was administrated to pregnant mice by intraperitoneally injection with 0, 0.05, 0.5 and 5.0 mg/kg B.W. for 5 times at 3 days interval on gestation days 1-16. There were no treatment-related effects of BPA on reproductive organ weight in male offsprings at 45 days-of-age, but body weight was the lowest in 5.0mg BPA group when compared to other groups (P<0.05). No differences in semen characteristics (sperm concentration, viability, motility and abnormality) were observed between the control and BPA treatment groups. The WBC, HB, HT, MCV, MCH, MCHC, albumin, BUN and total protein of blood hematological and chemical values in male offsprings were not difference for any treatment groups, but RBC value in BPA groups was significantly increased comparing to the control group (P<0.05). The PLT value was slightly higher in 5.0mg BPA groups than in any other group, but not significantly difference among the experimental groups. In female offsprings, the effects of BPA didn't affect to the body and ovary weight, but the uterus weight in 5.0mg BPA group was slightly heavier than that of control group (P>0.05). No statically significant difference in blood hematological values in female offsprings were observed between the control group and BPA groups, but the concentration of albumin and BUN were significantly higher in 0.5mg BPA group when compared to control and other BPA treatment groups (P<0.05). The histological evaluation of testis and ovary in growing offspring at 45 days-of-age was not difference between the control group and BPA groups, but endometriosis of the uterus in female offspring was dramatically increased in 0.5 and 5.0mg BPA groups. These founding suggest that low concentration of BPA might not have a important role on reproductive ability or blood metabolite in offspring of pregnant dams treated with BPA.

Keywords

References

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