Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Effect of Bisphenol A Administration on Reproductive Toxicant of Dam and Sex Ratio of Pups in Pregnant Mice

임신중인 생쥐에 Bisphenol A 투여가 모체의 생식독성과 태아의 성비에 미치는 영향

  • Park Dong-Heon (College of Animal Resource Science, Kangwon National University) ;
  • Jang Hyun-Yong (College of Animal Resource Science, Kangwon National University) ;
  • Kim Choung-Ik (College of Animal Resource Science, Kangwon National University) ;
  • Cheong Hee-Tae (College of Animal Resource Science, Kangwon National University) ;
  • Park Coon-Keun (College of Animal Resource Science, Kangwon National University) ;
  • Yang Boo-Keun (College of Animal Resource Science, Kangwon National University)
  • 박동헌 (강원대학교 동물자원과학대학) ;
  • 장현용 (강원대학교 동물자원과학대학) ;
  • 김정익 (강원대학교 동물자원과학대학) ;
  • 정희태 (강원대학교 동물자원과학대학) ;
  • 박춘근 (강원대학교 동물자원과학대학) ;
  • 양부근 (강원대학교 동물자원과학대학)
  • Published : 2005.06.01
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Abstract

Bisphenol A (SPA), a environmental endocrine disruptor, is considered to bind to estrogen receptors and to regulate the expressions of estrogen responsive genes. This study was to evaluate the effect of SPA administration on body weight, sex ratio and litter size on 18 days in prenatal periods, the effect of reproductive organ weight and blood hematological values on 24 days postpartum in pregnant mice. The female mice was administrated to low doses of SPA (0, 0.05, 0.5 and 5.0 mg/kg B.W.) by intraperitoneal injection in gestation days $0\~15$ with 5 times at 3 days interval. The maternal body weight, litter size and sex ratios were similar to in all experimental groups, but body weights of male and female offspring was significantly lower in 5.0mg SPA group when compared to any other groups (P<0.05). No treatment-related effects on body weight, ovary weight and blood hematological values were observed in dams on 24 days after delivery. The uterine weight in 5.0mg SPA group was slightly higher than those of any other groups, but not significantly difference. The histological evaluation of ovary in dam mice on 24 days after dilivery was not difference in all experimental groups, but the endometriosis of uterus in dam mice were significantly increased in 0.5mg SPA group when compared to control group. These results indicates that low concentration of SPA should not be considered as a selective reproductive toxicant.

Keywords

References

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