Journal of Pharmaceutical Investigation

  • 제35권4호
  • /
  • Pages.243-247
  • /
  • 2005
  • /
  • 2093-5552(pISSN)
  • /
  • 2093-6214(eISSN)
한국약제학회 (The Korean Society of Pharmaceutical Sciences and Technology)
권호 표지
DOI QR코드

DOI QR Code

Compaction Simulator Study on Pectin Introducing Dwell Time

  • 발행 : 2005.08.20
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Although many scientists have used pectin, its feasibility in terms of tablet manufacturability with a high speed machine has never been evaluated. Therefore, compactibility of different pectin types for large scale tableting operation has been evaluated. The compactibility behavior of powder pectins was studied by a compaction simulator. It was found that pectin on its own does not produce tablets of acceptable quality even at a punch velocity as low as 20 rpm (e.g. low tensile strengths, capping and lamination irrespective of applied compression force). Thus, dwell time was introduced and more hard compact was produced as relaxation time in die increases. It was concluded that frequent structural failure observed in both pectin types was due to lack of plastic deformation, poor compactibility and high elastic recovery.

키워드

참고문헌

  1. J.-G. Hardy, J.-N. Healey and J.-R. Reynolds, Evaluation of an enteric-coated delayed-release 5-aminosalicylic acid tablet in patients with inflanunatory bowel disease, Aliment. Pharmacol. Ther., 1, 273-280 (1987) https://doi.org/10.1111/j.1365-2036.1987.tb00627.x
  2. D.-R. Friend, Colonic drug delivery, Adv. Drug Deliv. Rev., 7, 149-199 (1991) https://doi.org/10.1016/0169-409X(91)90051-D
  3. W.-G. Cook, S.-S. Davis and I.-R. Wilding, Pectin matrix tablets for selective drug delivery to the colon, J. Pharm. Pharmacol., 45(suppl.2), 1120 (1993)
  4. A. Rubinstein, S. Pathak, M. Friedman and J.-S. Rokem, In vitro evaluation of calcium pectinate : a potential colon-specific drug delivery carrier, Proc. Int. Symp. Controlled Release Bioact. Mater., 17, 446-447 (1990)
  5. H. Kim and R. Fassihi, Optimal drug delivery for targeting to the colon, Controlled Release Soci, Inc. Bioact. Mater. Baltimore, Maryland, August, 21-22, 125-126 (1996)
  6. M. Ashford, J.-T. Fell, D. Attwood, H. Sharma and P.-J. Woodhead, An evaluation of pectin as a carrier for drug targeting to the colon, J. Controlled Release., 26, 213-220 (1993) https://doi.org/10.1016/0168-3659(93)90188-B
  7. J.-G. Hardy, C.-G. Wilson and E. Wood, Drug delivery to the proximal colon, J. Pharm. Pharmacol., 37, 874-877 (1985) https://doi.org/10.1111/j.2042-7158.1985.tb04992.x
  8. A.-J.Coupe, S.-S. Davis and I.-R. Wilding, Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects, Pharm. Res., 8, 360-364 (1991) https://doi.org/10.1023/A:1015849700421
  9. M. Ashford, J.-T. Fell, D. Attwood, H. Sharma and P.-J. Woodhead, Pectin as a carrier for drug targeting to the colon, J. Controlled Release., 30, 225-231 (1994) https://doi.org/10.1016/0168-3659(94)90028-0
  10. H. Kim and R. Fassihi, Application of a binary polymer system in drug release rate modulation 1. Characterization of release mechanism, J. Pharm. Sci., 86, 316-322 (1997a) https://doi.org/10.1021/js960302s
  11. H. Kim and R. Fassihi, Application of a binary polymer system in drug release rate modulation 2. Influence of formulation variables and hydrodynamic conditions on release kinetics, J. Pharm. Sci., 86, 323-328 (1997b) https://doi.org/10.1021/js960307p
  12. A.-R. Fassihi, A.-M. Mcphillips, S.-A. Uraizee and A.-M. Sakr, Potential use of Magnesium stearate and talc as dissolution retardants in the development of controlled drug delivery systems, Die Pharmaceutische Industrie., 56, 579-583 (1994)
  13. A.-R. Fassihi, J. Fabian and A.-M. Sakr, Application of response surface methodology to design optimization in formulation of a typical controlled release system, Die Pharmaceutische Industrie., 57, 1039-1043 (1995)
  14. L. Yang, G. Vankatesh and R. Fassihi, Characterization and compactibility and compressibility of poly(ethylene oxide) polymers for modified release application by compaction simulator, J. Pharm. Sci., 85, 1085-1090 (1996) https://doi.org/10.1021/js960039v
  15. R.-J. Roberts and R.-C. Rowe, The effect of punch velocity on the compaction of a variety of materials, J. Pharm. Pharmacol., 37, 377-384 (1985) https://doi.org/10.1111/j.2042-7158.1985.tb03019.x
  16. R.-J. Roberts and R.-C. Rowe, The effect of the relationship between punch and particle size on the compaction behavior of materials with varying deformation mechanisms, J. Pharm. Pharmacol., 38, 567-571 (1986) https://doi.org/10.1111/j.2042-7158.1986.tb03082.x
  17. G. Ragnarsson and J. Sjogren, Force-displacement measurements in tableting, J. PharmPharmaco., 37, 145-150 (1985)
  18. P. Humbert-Droz, D. Mordier and E. Doelker, Methodology for a better evaluation of the relation between mechanical strength of solids and polymorphic form, Acta Pharmaceutica Technologica., 29, 69-73 (1983)
  19. E.-G. Rippie and W. Danielson, Visceelastic stress/strain behavior of pharmaceutical tablets: analysis during unloading and postcompression period, J. Pharm. Sci., 70, 476-482 (1981) https://doi.org/10.1002/jps.2600700503
  20. J.-T. Fell and J.-M. Newton, Determination of tablet strength by the diametral-compression test, J. Pharm. Sci., 59, 688-691 (1970) https://doi.org/10.1002/jps.2600590523
  21. M. Celik and K. Marshall, Use of a compaction simulator system in tabletting research 1. Introduction to and initial experiments with the system, Drug Dev. Ind. Pharm., 5, 759-800 (1989)
  22. P.-V. Marshall and P. York, An investigation of the effect of the punch velocity on the compaction properties of ibuprofen, Powder Tech., 74, 171-177 (1993) https://doi.org/10.1016/0032-5910(93)87009-D
  23. S.-D. Bateman, M.-H. Rubinstein, R.-C. Rowe, R.-J. Roberts, P. Drew and A.-Y.-K. Ro, A comparative investigation of compression simulator, Int. J. Pharm., 49, 209-212 (1989) https://doi.org/10.1016/0378-5173(89)90344-X
  24. R.-W. Heckel, Density-pressure relationships in powder compaction, Trans. Metall. Soc. AIME., 221, 671-675 (1961a)
  25. R.-W. Heckel, An analysis of powder compaction phenomena, Trans. Metall. Soc. AIME., 221, 676-682 (1961b)
  26. J.-A. Hersey and J.-E. Rees, Deformation of particles during briquetting, Proc. the 2nd Particle Size Analysis Canl Society for Analyt. Chem. Bradford, 33, 212-213 (1970)
  27. S.-K. Dwivedi, R.-J. Oates and A.-G. Mitchell, Peak offset times as an indication of stress relaxation during tableting on a rotary tablet press, J. Pharm. Pharmacol., 43, 673-678 (1991) https://doi.org/10.1111/j.2042-7158.1991.tb03456.x
  28. W.-T. Morhead and E.-G. Rippie, Timing relationships among maxima of punch and die- wall stress and punch displacement during compaction of viscoelastic solids, J. Pharm. Sci., 11, 1020-1022 (1990)
  29. S.-K. Dwivedi, R.-J. Oates, and A.-G. Mitchell, Estimation of elastic recovery, work of decompression and Young's modulus using a rotary tablet press, J. Pharm. Pharmacol., 4, 459-466 (1992)

피인용 문헌

  1. Role of dwell on compact deformation during tableting: an overview vol.47, pp.3, 2017, https://doi.org/10.1007/s40005-017-0306-z