The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Synergic Effects of Eunkyo-san and Quinolones on 5 Strains of Aerobic Gram-negative Bacteria

은교산(銀翹散)과 Quinolone계 항생제의 병용(倂用)이 호기성 Gram(-) 세균주(細菌株)에 대한 시험관내(試驗管內) 항균력(抗菌力)에 미치는 영향

  • Jeon, Kwi-Ok (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Seo, Young-Ho (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Kwon, Eun-Hee (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Cho, Dong-Hee (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Park, Mee-Yeon (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Choi, Hae-Yun (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Kim, Jong-Dae (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Song, Kwang-Kyu (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University)
  • 전귀옥 (대구한의대학교 한의과대학 내과학교실) ;
  • 서영호 (대구한의대학교 한의과대학 내과학교실) ;
  • 권은희 (대구한의대학교 한의과대학 내과학교실) ;
  • 조동희 (대구한의대학교 한의과대학 내과학교실) ;
  • 박미연 (대구한의대학교 한의과대학 내과학교실) ;
  • 최해윤 (대구한의대학교 한의과대학 내과학교실) ;
  • 김종대 (대구한의대학교 한의과대학 내과학교실) ;
  • 송광규 (대구한의대학교 한의과대학 내과학교실)
  • Published : 2005.09.30
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Abstract

Objectives & Methods : In order to evaluate the in vitro synergic effects or Eunkyo-san which is a traditional poly-herbal formula that has been used in the treatment of respiratory diseases in oriental medicine, and quinolone antibiotics, rufloxacin (RUFX) and iprofloxacin(CPFX), experimentation was designed to determine minimal inhibitory concentration(MIC), $MIC_{50}\;and\;MIC_{90}$ of single use of quinolones and concomitant treatment with Eunkyo-san against 5 strains of aerobic gram negative bacteria, Escherichia coli, Klebsiella peumoniae, Hemophilus influenzae, Citrobacter freundii and Pseudomonas aeruginosae. Result : In the case of aerobic gram negative bacteria, the MIC, $MIC_{50}\;and\;MIC_{90}$ against Klebsiella peumoniae and Citrobacter freundii significantly decreased in concomitant-treated groups with Eunkyo-san compared to those of single-treated groups of RUFX and CPFX, respectively. However, no significant changes were demonstrated against Echerichia coli, Hemophilus influenzae and Pseudomonas aeruginosae. Conclusion : According to these results, concomitant use of Eunkyo-san against some strains of aerobic gram-negative bacteria dramatically increases in vitro antibacterial activity of RUFX and CPFX, and the increase and selectivity of antibacterial activities against these strains is attributable to Eunkyo-san, and not RUFX or CPFX activity.

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