Journal of Acupuncture Research
- Volume 22 Issue 2
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- Pages.43-53
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- 2005
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- 2586-288X(pISSN)
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- 2586-2898(eISSN)
Suppressive effects of a water extract of Ulmus davidiana Planch (Ulmaceae) on collagen-induced arthritis in mice
- Kil, Sang-Yong (Department of Acupuncture & Moxibustion, Graduate School of Oriental Medicine, Dongguk University) ;
- Kim, Kyung-Ho (Department of Acupuncture & Moxibustion, Graduate School of Oriental Medicine, Dongguk University) ;
- Lee, Seung-Deok (Department of Acupuncture & Moxibustion, Graduate School of Oriental Medicine, Dongguk University) ;
- Kim, Kap-Sung (Department of Acupuncture & Moxibustion, Graduate School of Oriental Medicine, Dongguk University) ;
- Yoon, Jong-Hwa (Department of Acupuncture & Moxibustion, Graduate School of Oriental Medicine, Dongguk University)
- Published : 2005.04.20
Abstract
Objective: Since Ulmus davidiana Planch (Ulmaceae) has been known to have anti-inflammatory and protective effects on damaged tissue, inflammation and bone among other functions, this study was undertaken to address whether the water extract of the bark of Ulmus davidiana Planch (Ulmaceae) (UD) could modulate the expression of inducible inflammatory cytokines in mice. The present study was also done in order to assess the therapeutic effects of UD in collagen-induced arthritis (CIA) in mice. Methods : DBA/1 mice were immunized with bovine type II collagen. After a second collagen immunization, mice were treated with UD orally at 100 mg/kg once a day for 3 weeks. Paws were evaluated macroscopically for redness, swelling and deformities. The levels of
Keywords
- Ulmus davidiana Planch (Ulmaceae);
- Collagen-induced arthritis;
- Cytokines $(TNF-{\alpha}$;
- $IL-1{\beta}$, IL-4, IL-10)