Journal of Acupuncture Research
- Volume 22 Issue 2
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- Pages.55-70
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- 2005
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- 2586-288X(pISSN)
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- 2586-2898(eISSN)
Inhibitory effect of Ulmus davidiana Planch extracts on bone resorption mediated by processing of cathepsin K in cultured mouse osteoclasts
- Park, Jun-Sung (Department of Acupuncture & Moxibustion, Graduate School of Oriental Medicine, Dongguk University) ;
- Kim, Kyung-Ho (Department of Acupuncture & Moxibustion, Graduate School of Oriental Medicine, Dongguk University) ;
- Jo, Hyun-Seog (Department of Acupuncture & Moxibustion, Graduate School of Oriental Medicine, Dongguk University) ;
- Kim, Kap-Sung (Department of Acupuncture & Moxibustion, Graduate School of Oriental Medicine, Dongguk University) ;
- Hwang, Min-Seob (Department of Acupuncture & Moxibustion, Graduate School of Oriental Medicine, Dongguk University)
- Published : 2005.04.20
Abstract
Objective: Ulmus davidiana Planch (Ulmaceae) has long been known to have anti-inflammnatory in the traditional Korean medicine. UD has been reported as a good enhancer for bone healing. Methods : In this experiment, we investigate the Inhibitory effects of UD on bone resorption using the bone cells culture. Different concentrations of crude extract of UD were added to mouse bone cells culture. The mitochondria activity of the bone cells after exposure was determined by colorimetric MIT assay. It was demonstrated that UD has potential effects on bone cells culture without any cytotoxicity. The most effective concentration of UD on bone cells were