Environmental Analysis Health and Toxicology

환경독성보건학회 (The Korean Society of Environmental Health and Toxicology)
권호 표지

실험적 간장해에 대한 강활의 보호효과

Protective Effects of Angelica koreana on Experimentally Induced Liver Injury

  • 윤수홍 (대구가톨릭대 약학과) ;
  • 하현 (상록병원 약제과)
  • Yoon Soo Hong (Department of Pharmacy, Catholic University of Taegu) ;
  • Ha Hun (Department of Pharmacy, Sangrok Hospital)
  • 발행 : 2005.06.01
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초록

The present study was carried out to find the possible protective effects of Angelica koreana water extract on biochemical parameters in benzo(a)pyrene (B(a)P)-induced liver injury in rats. B(a)P treatment (0.1 mg/kg, 1.p.) caused a liver damages, which led to biochemical alterations in serum and liver enzyme activities and serum lipid levels. The activities of liver marker enzymes, especially, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) were markedly changed in B(a)P treatment. Oral administration of Angelica koreana (50 mg/kg) recovered these biochemical Parameters to near normal levels. Therefore, the present results have revealed that Angelica koreana water extract might have the antihepatotoxic effect and consequently ameliorate liver damage associated with B(a)P in rats.

키워드

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