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Protective Effects of Angelica koreana on Experimentally Induced Liver Injury  

Yoon Soo Hong (Department of Pharmacy, Catholic University of Taegu)
Ha Hun (Department of Pharmacy, Sangrok Hospital)
Publication Information
Environmental Analysis Health and Toxicology / v.20, no.2, 2005 , pp. 161-165 More about this Journal
Abstract
The present study was carried out to find the possible protective effects of Angelica koreana water extract on biochemical parameters in benzo(a)pyrene (B(a)P)-induced liver injury in rats. B(a)P treatment (0.1 mg/kg, 1.p.) caused a liver damages, which led to biochemical alterations in serum and liver enzyme activities and serum lipid levels. The activities of liver marker enzymes, especially, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) were markedly changed in B(a)P treatment. Oral administration of Angelica koreana (50 mg/kg) recovered these biochemical Parameters to near normal levels. Therefore, the present results have revealed that Angelica koreana water extract might have the antihepatotoxic effect and consequently ameliorate liver damage associated with B(a)P in rats.
Keywords
Angelica koreana; benzo(a)pyrene; antihepatotoxic effect;
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