Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Anti-arthritic Properties of ShinEumHur-Herbal Acupuncture Assessed by Knee Circumference, Squeak Threshold and Weight Distribution Ratio in Rats

흰쥐의 adjuvant-induced knee arthritis에 대한 신음허 약침의 치료효과

  • Kim Gun-Ho (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung-Hee University) ;
  • Hahm Dae-Hyun (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung-Hee University) ;
  • Lee Han-Chang (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung-Hee University) ;
  • Yeom Mijung (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung-Hee University) ;
  • Han Dong-Oh (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung-Hee University) ;
  • Zhao Mei Ai (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung-Hee University) ;
  • Shim Insop (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung-Hee University) ;
  • Kim Jang-Hyun (Department of Oriental Pediatrics, Bundang Oriental Hospital, Dongguk University) ;
  • Lee Hye-Jung (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung-Hee University)
  • 김건호 (경희대학교 동서의학대학원 침구경락학교실) ;
  • 함대현 (경희대학교 동서의학대학원 침구경락학교실) ;
  • 이한창 (경희대학교 동서의학대학원 침구경락학교실) ;
  • 염미정 (경희대학교 동서의학대학원 침구경락학교실) ;
  • 한동오 (경희대학교 동서의학대학원 침구경락학교실) ;
  • 조미애 (경희대학교 동서의학대학원 침구경락학교실) ;
  • 심인섭 (경희대학교 동서의학대학원 침구경락학교실) ;
  • 김장현 (동국대학교 분당한방병원 한방소아과학교실) ;
  • 이혜정 (경희대학교 동서의학대학원 침구경락학교실)
  • Published : 2004.08.01
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Abstract

In order to examine the anti-arthritic properties of ShinEumHur(SEH)-herbal acupuncture, an adjuvant-induced arthritic rat was generated by the intra-articular injection of dried cells of Mycobacterium tuberculosis emulsified in squalene into the right knee joint. Fifty microliter of SEH extract was injected into Zusanli(ST36) acupoint on the ipsilateral hind paw every other day for 2 weeks. The body weight, knee circumference, squeak threshold, and weight distribution ratio were analyzed as the assessment methods addressing arthritic symptoms such as arthritic pain, edema, and tenderness. The weight distribution ratio was measured by a digital-type analgesia instrument using the dual channel scale that separately measures the weight the arthritic rat distributes to each hind paw, and thus quantifies both of swelling and pain severities at once. The therapeutic effects of SEH-herbal acupuncture, assessed by squeaking threshold and weight distribution ratio, were observed on 8th day after the arthritis induction as compared to saline group and control group. On 10th day, SEH-herbal acupuncture therapy significantly started to alleviate the growing pattern of knee circumference of an arthritic rat in the range of 0.2㎝. However, the loss of body weight was not significantly recovered. Taken together, the SEH-herbal acupuncture exhibited the significant therapeutic efficiency to treat adjuvant-induced monoarthritis in rat.

Keywords

References

  1. 재활의학 관절염의 재활 김상범;김진호;한태륜
  2. 대한침구학회지 v.11 no.1 退行性 膝關節炎에 對한 鍼治療 및 冷灸의 臨床的 考察 이영재;김경식
  3. 濟韓東醫學術院 論文集 v.4 no.1 退行性 膝關節炎에 대한 東西醫學的 比較 김미려;허수영;박기현
  4. 대한침구학회지 v.18 no.6 표고버섯 약침의 퇴행성 슬관절염 치료효과에 대한 임상연구 황규선;정형섭;백종엽;이상무;한희철;안호진;정동화
  5. 황제내경소문영추역해 양유걸
  6. 對譯 東醫寶鑑 허준
  7. 약침학 개론 및 임상 이혜정
  8. 대한침구학회지 v.16 no.3 膝關節炎에 대한 蜂毒藥鍼의 臨床的 考察 김지훈;이재동
  9. Biol. Pharm. Bull v.26 no.10 Therapeutic Effects of Hominis placenta Injection into an Acupuncture Point on the Inflammatory Response in Subchondral Bone Region of Adjuvante induced Polyarthritic Rat. Yeom MJ;Lee HC;Kim GH;Shim I;Lee HJ;Hahm DH.
  10. Pain v.90 no.3 Injection into an Acupuncture Point Reduces Arthritis Associated Edema and Nociceptive Responses Young-bae Kwon;Jae-dong Lee;Hye-jung Lee;Ho-jae Han;Woung-chon Mar;Alvin J. Beitz;Jang-hern Lee;Bee Venom
  11. 동의생리병리학회지 v.17 no.2 흰쥐의 adjuvant 유발 다발성 관절염에 대한 마황약침의 치료 효과 이한창;염미정;김건호;심인섭;최강덕;이혜정;함대현
  12. 대한침구학회지 v.12 no.1 蜂毒療法이 흰쥐의 膝關節 炎症性浮腫에 미치는 영향 도원석;장준혁;김경호;윤종화;김갑성
  13. Journal of Veterinary Science v.3 no.4 The antinociceptive and anti-inflammatory effect of ethylacetate extracts from Bang-Poong (Radix ledebouriellae) on the Frenud's adjuvant-induced arthritis in rats Kim HW;Kwon YB;Ham TW;Roh DH;Yoon SY;Han HJ;Kang SK;Mar WC;Yang IS;Beitz AJ;Lee JH
  14. The Journal of Dong-Guk Oriental Medicine v.5 no.1 六味地黃湯에 대한 文獻的 考察 이원석;박선동
  15. 약침요법시술지침서 대한약침학회
  16. Journal of Neuroscience Methods v.115 Two variables that can be used as pain indices in experimental animal models of arthritis Yun Cho Yu;Chang Hoon Kim;Yeongsu Lyu;James J. Grady;Jin Mo Chung
  17. Neuroscience v.94 no.2 Supraspinal metabolic activity changes in the rat during adjuvant monoarthritis Neto FL;Schadrack J;Ableitner A;Castro-lopes JM;Bartenstein P;Zeiglganxberger W;tolle TR.
  18. Arthritis Rheum v.48 no.2 Mapping and functrional characterization of rat chromosome 4 regions that regulate arthritis models and phenotypes in congenic strains Liselotte Backdahl;Ulrica Ribbhammar;Johnny C. Lorentzen.
  19. 원광한의학회지 v.7 no.1 약침이 Freund's Complete Adjuvant와 Peptidoglycan Polysaccharide에 의해서 유발된 백서의 관절염에 미치는 영향 이병철;한명관;나창수
  20. 중의증상감별진단학 중의연구원
  21. 위생보감 나천익
  22. 한약방제학 한약대학 한약학 교수연구회(편저)
  23. 한방재활의학과학회지 v.12 no.3 육미지황탕가미방 추출물이 골형성 관련 물질인 OTN과 BMP2의 유전자 전사활성에 미치는 영향 김윤갑;이응세;차윤엽
  24. 동국대대학원 박사학위논문 Study on bone resorption & osteoporosis by yukmi-jihwang-tang-carthamus tinctorius L. extracts 김정철
  25. 침구학(上) 전국한의과대학 침구;경혈학교실(편저)
  26. Medical Acupuncture Acupuncture for rhematological problems Anne Virginia Camp;Jacqueline Filshie;Adrian White
  27. Neuroscience v.78 The potential role of spinal cord cyclooxygenase-2 in the development of Freund's complete adjuvant-induced changes in hyperalgesia and allodynia Hay CH;Trevethick MA;Wheeldon A;Bowers JS;DE Belleroche JS
  28. J. Pharmacol. Toxicol. Methods v.31 no.2 Weight bearing as an objective measure of arthritis pain in the rat. Schott E;Berge OG;Angeby-Moller K;Hammarstrom G;Dalsgaard CJ;Brodin E.
  29. Thesis for the degree of doctor of philosophy in oriental medicine, graduate school of east-west medical science The effect of electroacupuncture on the chronic monoarthritis in rats Park HJ