Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Gamgung-tang on Lymphocyte Activities in Immunodeficiency Mice

감궁탕이 면역기능 저하 마우스의 임파구활성에 미치는 영향

  • Shon Yun Hee (Department of Pharmacology and Intractable Disease Research Center, College of Medicine, Dongguk University) ;
  • Kim Ho Chang (Department of Pharmacology and Intractable Disease Research Center, College of Medicine, Dongguk University) ;
  • Moon Ji Sun (Department of Pharmacology and Intractable Disease Research Center, College of Medicine, Dongguk University) ;
  • Baek Tae Seon (Department of Pharmacology and Intractable Disease Research Center, College of Medicine, Dongguk University) ;
  • Kim Cheorl Ho (Department of Biochemistry and Molecular Biology, College of Oriental Medicine, Dongguk University) ;
  • Jeon Byung Hun (Department of Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Nam Kyung Soo (Department of Pharmacology and Intractable Disease Research Center, College of Medicine, Dongguk University)
  • 손윤희 (동국대학교 난치병한양방치료연구센터, 의과대학 약리학교실) ;
  • 김호창 (동국대학교 난치병한양방치료연구센터, 의과대학 약리학교실) ;
  • 문지선 (동국대학교 난치병한양방치료연구센터, 의과대학 약리학교실) ;
  • 백태선 (동국대학교 난치병한양방치료연구센터, 의과대학 약리학교실) ;
  • 김철호 (동국대학교 한의과대학 생화학분자생물학교실) ;
  • 전병훈 (원광대학교 한의과대학 병리학교실) ;
  • 남경수 (동국대학교 난치병한양방치료연구센터, 의과대학 약리학교실)
  • Published : 2004.08.01
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Abstract

This study was purposed to investigate the effect of Gamgung-tang(GGT) on immune responses induced by glucocorticoid in mice. GGT solution was treated by intraperitoneal injection for 7 days after glucocorticoid treatment(80㎎/㎏). And then B and T cell proliferation and cytolytic activity of natural killer(NK) cells were measured. There was 25% inhibition in B cell proliferation with treatment of glucocorticoid. However, B cell proliferation was not influenced by GGT treatment. T cell proliferation was also inhibited by 18.4% with treatment of glucocorticoid. On the other hand, T cell proliferation was increased dose-dependent manner in GGT treated group. Furthermore in purified T cell, the proliferation was furtherly increased than non-purified T cell. At concentration of 18㎎/mouse GGT, purified T cell proliferation was increase to above level of normal group. The cytotoxic activity of NK cell was decreased by 35.3% with treatment of glucocorticoid. In GGT treated group, the cytotoxic activity of NK cell was increased to the normal level. In purified NK cell, the cytolytic activity of NK cell was further increased than non-purifed NK cell. These results suggest that GGT may proliferate T cell that is suppressed by glucocorticoid, and activate NK cell activity.

Keywords

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