Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of the Evaporating Extract from Liquor of Fermentation Using Mycelium of Phellinus linteus on the Expression of Inflammatory Proteins and the Generation of Reactive Oxygen Species

상황버섯 균사체를 이용한 발효주의 추출물이 염증관련 단백질의 발현과 세포내 활성산소 생성에 미치는 영향

  • Lee Jun Hyuk (Department of Anatomy, College of Oriental Medicine, Dong-Eui University) ;
  • Choi Yung Hyun (Department of Biochemistry, College of Oriental Medicine, Dong-Eui University) ;
  • Lee Yong Tae (Department of Physiology, College of Oriental Medicine, Dong-Eui University) ;
  • Choi Sung Hee (Department of Food and Nutrition, College of Human Ecology, Deong-Eui University) ;
  • Chung Kyung Tae (Department of Life Science and Biotechnology, College of Natural Science, Dong-Eui University) ;
  • Jeong Young Kee (Department of Life Science and Biotechnology, College of Natural Science, Dong-Eui University) ;
  • Choi Byung Tae (Department of Anatomy, College of Oriental Medicine, Dong-Eui University)
  • 이준혁 (동의대학교 한의과대학 해부학교실) ;
  • 최영현 (동의대학교 한의과대학 생화학교실) ;
  • 이용태 (동의대학교 한의과대학 생리학교실) ;
  • 최성희 (동의대학교 생활과학대학 식품영양학과) ;
  • 정경태 (동의대학교 자연과학대학 생명응용과학과) ;
  • 정영기 (동의대학교 자연과학대학 생명응용과학과) ;
  • 최병태 (동의대학교 한의과대학 해부학교실)
  • Published : 2004.12.01
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Abstract

Phellinus linteus is known as a medicinal mushroom, which has the pharmaceutical activity on tumors and inflammatory diseases in traditional Oriental medicine. However, despite extensive pharmacological studies on P. linteus, the liquor of fermentation using mycelium of P. linteus(LFMP) has not been investigated. In the present study, it was examined the effect of the evaporating extract from LFMP(E-LFMP) on the expression of inflammatory proteins and the generation of reactive oxygen species in human hepatocarcinoma HepG2 cells. E-LFMP inhibited acetaldehyde-induced morphological change in HepG2 cells. Also, E-LFMP inhibits expression of inflammatory proteins including cyclooxygenase(COX)-1 and COX-2 through suppressing nuclear translocation of nuclear factor κB(NF-κB) and degradation of inhibitory κBα(IκBα). In addition, E-LFMP inhibits generation of reactive oxygen species(ROS) by hydrogen peroxide(H₂O₂) in HepG2 cells. These results suggest that LFMP has the pharmaceutical, especially anti-inflammatory, activity similar to P. linteus mushroom.

Keywords

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