[KSCI] Korea Science Citation Index Service

Effect of the Evaporating Extract from Liquor of Fermentation Using Mycelium of Phellinus linteus on the Expression of Inflammatory Proteins and the Generation of Reactive Oxygen Species

Lee Jun Hyuk (Department of Anatomy, College of Oriental Medicine, Dong-Eui University)
Choi Yung Hyun (Department of Biochemistry, College of Oriental Medicine, Dong-Eui University)
Lee Yong Tae (Department of Physiology, College of Oriental Medicine, Dong-Eui University)
Choi Sung Hee (Department of Food and Nutrition, College of Human Ecology, Deong-Eui University)
Chung Kyung Tae (Department of Life Science and Biotechnology, College of Natural Science, Dong-Eui University)
Jeong Young Kee (Department of Life Science and Biotechnology, College of Natural Science, Dong-Eui University)
Choi Byung Tae (Department of Anatomy, College of Oriental Medicine, Dong-Eui University)

Publication Information

Journal of Physiology & Pathology in Korean Medicine / v.18, no.6, 2004 , pp. 1825-1831 More about this Journal

Abstract

Phellinus linteus is known as a medicinal mushroom, which has the pharmaceutical activity on tumors and inflammatory diseases in traditional Oriental medicine. However, despite extensive pharmacological studies on P. linteus, the liquor of fermentation using mycelium of P. linteus(LFMP) has not been investigated. In the present study, it was examined the effect of the evaporating extract from LFMP(E-LFMP) on the expression of inflammatory proteins and the generation of reactive oxygen species in human hepatocarcinoma HepG2 cells. E-LFMP inhibited acetaldehyde-induced morphological change in HepG2 cells. Also, E-LFMP inhibits expression of inflammatory proteins including cyclooxygenase(COX)-1 and COX-2 through suppressing nuclear translocation of nuclear factor κB(NF-κB) and degradation of inhibitory κBα(IκBα). In addition, E-LFMP inhibits generation of reactive oxygen species(ROS) by hydrogen peroxide(H₂O₂) in HepG2 cells. These results suggest that LFMP has the pharmaceutical, especially anti-inflammatory, activity similar to P. linteus mushroom.

Keywords

Phellinus linteus; cyclooxygenase; acetaldehyde; nuclear factor κB; reactive oxygen species;

Citations & Related Records

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