Korean Membrane Journal

The Membrane Society of Korea (한국막학회)
권호 표지

Preparation and Swelling Behaviors of Hydrogel Composed of Alginate, Poly(N-isopropylacrylamide) and Polyaniline

  • Lee, Young Moo (School of Chemical Engineering, College of Engineering, Hanyang University) ;
  • Seo, Sung Mi (School of Chemical Engineering, College of Engineering, Hanyang University) ;
  • Lee, Sang Bong (Clean System Team, Korea Institute of Industrial Technology)
  • Published : 2004.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

Comb-type graft hydrogels composed of alginate and poly(N-isopropylacrylamide) (PNIPAAm) were prepared to manifest rapid temperature and pH sensitivity. To appear the electro-sensitivity, the polyaniline, conducting polymer, was added into the matrix. The swelling kinetics and ratios were compared under the various compositions of polyaniline. The swelling behaviors revealed that conducting polymer/hydrogel composites could control the swelling ratio and kinetics. The addition of polyaniline in the matrix improved the thermal stability in comparison with that of the hydrogel without polyaniline. In temperature sensitivity, the adding the polyaniline into the matrix decreased the degree of change in the swelling ratio. The swelling ratios continuously increased with increasing pH values. The drug release rate from the hydrogel increased with the adding the polyaniline and the applying the direct voltage to the hydrogels.

Keywords

References

  1. H. K. Ju, S. Y. Kim, and Y. M. Lee, 'pH/temperature-responsive behaviors of semi-IPN and comb-type graft hydrogels composed of alginate and poly(N-isopropylacrylamide)', Polymer, 42, 6851 (2001)
  2. N. A. Peppas, P. Bures, W. Leobandung, and W. Ichikawa, 'Hydrogels in pharmaceutical formulations', Eur. J. Pharm. Biopharm., 50, 27 (2000)
  3. O. Hirasa, S. Ito, A. Yamauchi, S. Fujishige, and H. Ichijo, 'Thermoresponsive polymer hydrogel', Polymer gels, fundamentals and biomedical application Plenum Press, New York, 247 (1991)
  4. H. K. Ju, S. Y. Kim, S. J. Kim, and Y. M. Lee, 'pH/temperature-responsive semi-IPN hydrogels composed of alginate and poly(N-isopropylacrylamide)', J. Appl. Polym. Sci., 83, 1128 (2002)
  5. D. E. Tallman and G. G. Wallace, 'Preparation and preliminary characterization of a poly (4-vinyl-pyridine) complex of a water-soluble polyaniline', Synthetic Metals, 90, 13 (1997)
  6. B. Massoumi and A. Entezami, 'Controlled release of sulfosalicylic acid during electrochemical switching of conducting polymer bilayers', European Polymer Journal, 37, 015 (2001)
  7. B. G. Kabra and S. H. Gehrke, 'Synthesis of fastresponse, temperature-sensitive poly(N-isopropylacrylamide) gel', Polym. Commun., 32, 322 (1991)
  8. X. S. Wu, A. S. Hoffman, and P. Yager, 'Synthesis and characterization of thermally reversible macroporous poly(N-isopropylacrylamide) hydrogels', J. Polym. Sci. Part A: Polym. Chem., 30, 2121 (1992)
  9. X. Z. Zhang and R. X. Zhuo, 'Dynamic properties of Temperature-Sensitive poly(N-isopropylacrylamide) Gel Cross-Linked through Siloxane Linkage', Langmuir, 17, 12 (2001)
  10. Y. Qin, 'Absorption characteristics of alginate wound dressings', J Appl. Polym. Sci., 91, 953 (2004)
  11. I. W. Sutherland, 'Structure-function relationships in microbial exopolysaccharides', Biotechnology Advances, 12, 393-448 (1994)
  12. S. Y. Kim, S. M. Cho, Y. M. Lee, and S. J. Kim, 'Thermo- and pH-responsive behaviors of graft copolymer and blend based on chitosan and N-isopropylacrylamide', J. Appl. Polym. Sci., 78, 1381 (2000)
  13. W. R. Gombotz and S. F. Wee, 'Protein release from alginate matrices', Adv. Drug Delivery Rev., 31, 267 (1998)
  14. A. Kikuchi, M. Kawabuchi, A. Watanabe, M. Sugihara, Y. Sakurai, and T. Okano, 'Effect of $Ca^{2+}$-alginate gel dissolution on release of dextran with different molecular weights', J. Contr. Rel., 58, 21 (1999)
  15. Y. S. Choi, S. R. Hong, Y. M Lee, K. W. Song, M. H. Park, and Y. S. Nam, 'Study on gelatin-containing artificial skin: I. Preparation and characteristics of novel gelatin-alginate sponge', Biomaterials, 20, 409 (1999)