Browse > Article

Preparation and Swelling Behaviors of Hydrogel Composed of Alginate, Poly(N-isopropylacrylamide) and Polyaniline  

Lee, Young Moo (School of Chemical Engineering, College of Engineering, Hanyang University)
Seo, Sung Mi (School of Chemical Engineering, College of Engineering, Hanyang University)
Lee, Sang Bong (Clean System Team, Korea Institute of Industrial Technology)
Publication Information
Korean Membrane Journal / v.6, no.1, 2004 , pp. 37-43 More about this Journal
Abstract
Comb-type graft hydrogels composed of alginate and poly(N-isopropylacrylamide) (PNIPAAm) were prepared to manifest rapid temperature and pH sensitivity. To appear the electro-sensitivity, the polyaniline, conducting polymer, was added into the matrix. The swelling kinetics and ratios were compared under the various compositions of polyaniline. The swelling behaviors revealed that conducting polymer/hydrogel composites could control the swelling ratio and kinetics. The addition of polyaniline in the matrix improved the thermal stability in comparison with that of the hydrogel without polyaniline. In temperature sensitivity, the adding the polyaniline into the matrix decreased the degree of change in the swelling ratio. The swelling ratios continuously increased with increasing pH values. The drug release rate from the hydrogel increased with the adding the polyaniline and the applying the direct voltage to the hydrogels.
Keywords
hydrogels; polyaniline; conducting polymer; electric stimulus alginate;
Citations & Related Records
연도 인용수 순위
  • Reference
1 H. K. Ju, S. Y. Kim, and Y. M. Lee, 'pH/temperature-responsive behaviors of semi-IPN and comb-type graft hydrogels composed of alginate and poly(N-isopropylacrylamide)', Polymer, 42, 6851 (2001)
2 D. E. Tallman and G. G. Wallace, 'Preparation and preliminary characterization of a poly (4-vinyl-pyridine) complex of a water-soluble polyaniline', Synthetic Metals, 90, 13 (1997)
3 A. Kikuchi, M. Kawabuchi, A. Watanabe, M. Sugihara, Y. Sakurai, and T. Okano, 'Effect of $Ca^{2+}$-alginate gel dissolution on release of dextran with different molecular weights', J. Contr. Rel., 58, 21 (1999)
4 H. K. Ju, S. Y. Kim, S. J. Kim, and Y. M. Lee, 'pH/temperature-responsive semi-IPN hydrogels composed of alginate and poly(N-isopropylacrylamide)', J. Appl. Polym. Sci., 83, 1128 (2002)
5 X. S. Wu, A. S. Hoffman, and P. Yager, 'Synthesis and characterization of thermally reversible macroporous poly(N-isopropylacrylamide) hydrogels', J. Polym. Sci. Part A: Polym. Chem., 30, 2121 (1992)
6 Y. Qin, 'Absorption characteristics of alginate wound dressings', J Appl. Polym. Sci., 91, 953 (2004)
7 X. Z. Zhang and R. X. Zhuo, 'Dynamic properties of Temperature-Sensitive poly(N-isopropylacrylamide) Gel Cross-Linked through Siloxane Linkage', Langmuir, 17, 12 (2001)
8 B. Massoumi and A. Entezami, 'Controlled release of sulfosalicylic acid during electrochemical switching of conducting polymer bilayers', European Polymer Journal, 37, 015 (2001)
9 Y. S. Choi, S. R. Hong, Y. M Lee, K. W. Song, M. H. Park, and Y. S. Nam, 'Study on gelatin-containing artificial skin: I. Preparation and characteristics of novel gelatin-alginate sponge', Biomaterials, 20, 409 (1999)
10 O. Hirasa, S. Ito, A. Yamauchi, S. Fujishige, and H. Ichijo, 'Thermoresponsive polymer hydrogel', Polymer gels, fundamentals and biomedical application Plenum Press, New York, 247 (1991)
11 B. G. Kabra and S. H. Gehrke, 'Synthesis of fastresponse, temperature-sensitive poly(N-isopropylacrylamide) gel', Polym. Commun., 32, 322 (1991)
12 I. W. Sutherland, 'Structure-function relationships in microbial exopolysaccharides', Biotechnology Advances, 12, 393-448 (1994)
13 W. R. Gombotz and S. F. Wee, 'Protein release from alginate matrices', Adv. Drug Delivery Rev., 31, 267 (1998)
14 N. A. Peppas, P. Bures, W. Leobandung, and W. Ichikawa, 'Hydrogels in pharmaceutical formulations', Eur. J. Pharm. Biopharm., 50, 27 (2000)
15 S. Y. Kim, S. M. Cho, Y. M. Lee, and S. J. Kim, 'Thermo- and pH-responsive behaviors of graft copolymer and blend based on chitosan and N-isopropylacrylamide', J. Appl. Polym. Sci., 78, 1381 (2000)