Biotechnology and Bioprocess Engineering:BBE

  • 제9권3호
  • /
  • Pages.212-216
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  • 2004
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  • 1226-8372(pISSN)
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  • 1976-3816(eISSN)
한국생물공학회 (The Korean Society for Biotechnology and Bioengineering)
권호 표지

Peroxynitrite-scavenging Constituents from the Brown Alga Sargassum thunbergii

  • Youngwan Seo (Division of Ocean Science, Korea Maritime University) ;
  • Lee, Hee-Jung (Research Institute of Marine Science and Technology(RIMST), Korea Maritime University) ;
  • Park, Ki-Eui (Division of Ocean Science, Korea Maritime University) ;
  • Kim, You-Ah (Division of Ocean Science, Korea Maritime University) ;
  • Ahn, Jong-Woong (Division of Ocean Science, Korea Maritime University) ;
  • Yoo, Jong-Su (Research Institute of Marine Science and Technology(RIMST), Korea Maritime University) ;
  • Lee, Burm-Jong (Department of Chemistry, Inje University)
  • 발행 : 2004.06.01
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초록

Peroxynitrite formation in vivo is implicated in numerous human diseases and there is considerable interest in the use of antioxidants and natural products for their treatment. The three components (1-3) isolated from Sargassum thunbergii as well as the organic solvent-soluble fractions and the aqueous layer of S. thunbergii were evaluated for their potential to scavenge authentic ONOO$\^$-/ and ONOO$\^$-/ derived from 3-morpholinosydnonimine (SIN-1). The antioxidant activity of the individual fractions was in the order of 85% aqueous (aq.) MeOH＞n$\^$-/ BuOH＞n-hexane＞H$_2$O. The three known compounds, sargahydroquinoic acid (1), sargaquinoic acid (2) and sargachromenol (3) showed peroxynitrite-scavenging activities comparable to those of L-ascorbic acid and penicillamine. These results showed a possible antioxidant activity in major constituents of S. thunbergii.

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