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Peroxynitrite-scavenging Constituents from the Brown Alga Sargassum thunbergii  

Youngwan Seo (Division of Ocean Science, Korea Maritime University)
Lee, Hee-Jung (Research Institute of Marine Science and Technology(RIMST), Korea Maritime University)
Park, Ki-Eui (Division of Ocean Science, Korea Maritime University)
Kim, You-Ah (Division of Ocean Science, Korea Maritime University)
Ahn, Jong-Woong (Division of Ocean Science, Korea Maritime University)
Yoo, Jong-Su (Research Institute of Marine Science and Technology(RIMST), Korea Maritime University)
Lee, Burm-Jong (Department of Chemistry, Inje University)
Publication Information
Biotechnology and Bioprocess Engineering:BBE / v.9, no.3, 2004 , pp. 212-216 More about this Journal
Abstract
Peroxynitrite formation in vivo is implicated in numerous human diseases and there is considerable interest in the use of antioxidants and natural products for their treatment. The three components (1-3) isolated from Sargassum thunbergii as well as the organic solvent-soluble fractions and the aqueous layer of S. thunbergii were evaluated for their potential to scavenge authentic ONOO$\^$-/ and ONOO$\^$-/ derived from 3-morpholinosydnonimine (SIN-1). The antioxidant activity of the individual fractions was in the order of 85% aqueous (aq.) MeOH＞n$\^$-/ BuOH＞n-hexane＞H$_2$O. The three known compounds, sargahydroquinoic acid (1), sargaquinoic acid (2) and sargachromenol (3) showed peroxynitrite-scavenging activities comparable to those of L-ascorbic acid and penicillamine. These results showed a possible antioxidant activity in major constituents of S. thunbergii.
Keywords
Sargassum thunbergii; peroxynitrite; 3-morpholinosydnonimine (SIN-1); plastoquinone; NMR assignment;
Citations & Related Records

Times Cited By Web Of Science : 9  (Related Records In Web of Science)
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